DBU-Mediated Reaction of 3-Chlorooxindole and 9-Xanthyl Fluorene for Synthesis of 3-Arylidene Oxindole
Issued Date
2025-01-01
Resource Type
eISSN
21935815
Scopus ID
2-s2.0-85217426488
Journal Title
Asian Journal of Organic Chemistry
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Journal of Organic Chemistry (2025)
Suggested Citation
Purahong N., Teerawatananond T., Chotsaeng N., Janthakit P., Nalaoh P., Promarak V., Kuhakarn C., Meesin J. DBU-Mediated Reaction of 3-Chlorooxindole and 9-Xanthyl Fluorene for Synthesis of 3-Arylidene Oxindole. Asian Journal of Organic Chemistry (2025). doi:10.1002/ajoc.202400660 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/105327
Title
DBU-Mediated Reaction of 3-Chlorooxindole and 9-Xanthyl Fluorene for Synthesis of 3-Arylidene Oxindole
Corresponding Author(s)
Other Contributor(s)
Abstract
This work reports a new route for the synthesis of 3-(9H-fluoren-9-ylidene)indolin-2-one derivatives via the reaction of 3-chlorooxindoles and O-ethyl S-(9H-fluoren-9-yl) carbonodithioates mediated by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The reactions readily proceeded at room temperature, enable a collection of 3-alkenyl oxindoles to be prepared within a short reaction time (15 minutes). The 3-alkenyl oxindoles can be easily converted to 3-fluorenyl oxindoles by NaBH4 reduction.