Cross-Sectional Area of the Tibial Nerve in Diabetic Peripheral Neuropathy Patients: A Systematic Review and Meta-Analysis of Ultrasonography Studies
Issued Date
2022-12-01
Resource Type
ISSN
1010660X
eISSN
16489144
Scopus ID
2-s2.0-85144513326
Pubmed ID
36556898
Journal Title
Medicina (Lithuania)
Volume
58
Issue
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Medicina (Lithuania) Vol.58 No.12 (2022)
Suggested Citation
Senarai T., Pratipanawatr T., Yurasakpong L., Kruepunga N., Limwachiranon J., Phanthong P., Meemon K., Yammine K., Suwannakhan A. Cross-Sectional Area of the Tibial Nerve in Diabetic Peripheral Neuropathy Patients: A Systematic Review and Meta-Analysis of Ultrasonography Studies. Medicina (Lithuania) Vol.58 No.12 (2022). doi:10.3390/medicina58121696 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85186
Title
Cross-Sectional Area of the Tibial Nerve in Diabetic Peripheral Neuropathy Patients: A Systematic Review and Meta-Analysis of Ultrasonography Studies
Other Contributor(s)
Abstract
Background: There is a link between diabetic peripheral neuropathy (DPN) progression and the increase in the cross-sectional area (CSA) of the tibial nerve at the ankle. Nevertheless, no prior meta-analysis has been conducted to evaluate its usefulness for the diagnosis of DPN. Methods: We searched Google Scholar, Scopus, and PubMed for potential studies. Studies had to report tibial nerve CSA at the ankle and diabetes status (DM, DPN, or healthy) to be included. A random-effect meta-analysis was applied to calculate pooled tibial nerve CSA and mean differences across the groups. Subgroup and correlational analyses were conducted to study the potential covariates. Results: The analysis of 3295 subjects revealed that tibial nerve CSA was 13.39 mm2 (CI: 10.94–15.85) in DM patients and 15.12 mm2 (CI: 11.76–18.48) in DPN patients. The CSA was 1.93 mm2 (CI: 0.92–2.95, I2 = 98.69%, p < 0.01) larger than DPN-free diabetic patients. The diagnostic criteria of DPN and age were also identified as potential moderators of tibial nerve CSA. Conclusions: Although tibial nerve CSA at the ankle was significantly larger in the DPN patients, its clinical usefulness is limited by the overlap between groups and the inconsistency in the criteria used to diagnose DPN.