Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry

dc.contributor.authorDi Vincenzo M.
dc.contributor.authorPrachason T.
dc.contributor.authorSampogna G.
dc.contributor.authorArias-Magnasco A.
dc.contributor.authorLin B.D.
dc.contributor.authorPries L.K.
dc.contributor.authorvan Os J.
dc.contributor.authorRutten B.P.F.
dc.contributor.authorBarzilay R.
dc.contributor.authorFiorillo A.
dc.contributor.authorGuloksuz S.
dc.contributor.correspondenceDi Vincenzo M.
dc.contributor.otherMahidol University
dc.date.accessioned2025-03-06T18:14:46Z
dc.date.available2025-03-06T18:14:46Z
dc.date.issued2025-12-01
dc.description.abstractThis study aimed to assess the independent and joint associations of genomic and exposomic liabilities for schizophrenia with distressing psychotic experiences (PEs) and their persistence in early adolescence. The Adolescent Brain and Cognitive Development Study data from children with European ancestry were used (N = 5122). The primary outcome was past-month distressing PEs at the 3-year follow-up. Secondary outcomes were distressing PEs at varying cutoffs of persistence. Multilevel logistic regression models were used to test the associations of binary modes (>75th percentile) of polygenic risk score for schizophrenia (PRS-SCZ75) and exposome score for schizophrenia (ES-SCZ75) on the outcomes. Relative excess risk due to interaction (RERI) calculation indicated additive interaction. When analyzed independently, PRS-SCZ75 was not significantly associated with past-month distressing PEs but with lifetime (OR 1.29 [95% CI 1.08, 1.53]) and repeating distressing PEs ≥2 waves (OR 1.34 [95% CI 1.08, 1.65]); whereas, ES-SCZ75 was consistently associated with all outcomes, with increasing strength of association as a function of PEs persistence (one wave: OR 2.77 [95% CI 2.31, 3.31]; two waves: OR 3.16 [95% CI 2.54, 3.93]; three waves: OR 3.93 [95% CI 2.86, 5.40]; four waves: OR 3.65 [95% CI 2.34, 5.70]). When considered jointly, ES-SCZ75 and PRS-SCZ75 did not additively interact to predict past-month distressing PEs but showed significant additive interactions for lifetime (RERI = 1.26 [95%CI 0.14, 2.38]) and repeating distressing PEs ≥2 waves (RERI = 1.79 [95%CI 0.35, 3.23]). Genomic and exposomic liabilities for schizophrenia were independently and jointly associated with distressing PEs and their persistence in early adolescence.
dc.identifier.citationSchizophrenia Vol.11 No.1 (2025)
dc.identifier.doi10.1038/s41537-025-00569-2
dc.identifier.eissn27546993
dc.identifier.scopus2-s2.0-85218710607
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/105506
dc.rights.holderSCOPUS
dc.subjectPsychology
dc.subjectNeuroscience
dc.subjectMedicine
dc.titleIndependent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85218710607&origin=inward
oaire.citation.issue1
oaire.citation.titleSchizophrenia
oaire.citation.volume11
oairecerif.author.affiliationUniversity Medical Center Utrecht
oairecerif.author.affiliationThe Children's Hospital of Philadelphia
oairecerif.author.affiliationUniversità degli Studi della Campania Luigi Vanvitelli
oairecerif.author.affiliationYale School of Medicine
oairecerif.author.affiliationFaculty of Medicine Ramathibodi Hospital, Mahidol University
oairecerif.author.affiliationKing's College London
oairecerif.author.affiliationMaastricht Universitair Medisch Centrum+
oairecerif.author.affiliationUniversity of Pennsylvania Perelman School of Medicine

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