Dietary intake, lifestyle, inflammatory markers, gene polymorphisms and their relationship to development of type 2 diabetes among rural Thais in Sung Noen district, Nakhon Ratchasima province : a cohort study
Issued Date
2024
Copyright Date
2020
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xiv, 188 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (Ph.D. (Tropical Medicine))--Mahidol University, 2019
Suggested Citation
Jirayu Lainampetch Dietary intake, lifestyle, inflammatory markers, gene polymorphisms and their relationship to development of type 2 diabetes among rural Thais in Sung Noen district, Nakhon Ratchasima province : a cohort study. Thesis (Ph.D. (Tropical Medicine))--Mahidol University, 2019. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/92257
Title
Dietary intake, lifestyle, inflammatory markers, gene polymorphisms and their relationship to development of type 2 diabetes among rural Thais in Sung Noen district, Nakhon Ratchasima province : a cohort study
Author(s)
Abstract
Type 2 diabetes mellitus (T2DM) is an important global public health problem. The number of T2DM cases is continuously increasing every year. Apart from major contributing risk factors of T2DM, the chronic low-grade inflammation influenced by inflammatory markers and genetic polymorphisms have been proposed to be related with the disease for over a decade. This study therefore aimed to determine the association of inflammatory markers, including tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and C-reactive protein (CRP), their related single nucleotide polymorphisms (SNPs); rs1800629, rs1800796, rs3093059, rs1061622, rs2228145 and rs372996, and other risk factors on the development of T2DM using the 2-year cohort study. A total of 248 diabetes-free subjects, aged 35-70 years who live in Sung Noen district, Nakhon Ratchasima Province, were completely followed for 2 years. After the 2-year follow-up, 18.6% of the total subjects had developed T2DM. The Longitudinal comparisons obviously showed the significant differences of several anthropometric and biochemical indices between the diabetic and non-diabetic groups throughout the follow-up period. The relationship of these indices, as well as dietary habits and exercise, with inflammatory marker levels was also found. The risk of developing T2DM was significantly increased in the subjects with the high level of baseline CRP (OR = 4.02, P = 0.001), and a stronger impact was found with combination of high CRP and IL-6 levels (OR = 5.11, P = 0.021). One-year inflammatory markers variation analysis also revealed the significant association of the elevated TNF-α and T2DM (OR = 4.88, P = 0.048). The effect of the gene polymorphisms on inflammatory markers levels were moderately found. The substitution of T to G on TNFRSF1B gene (rs1061622) was associated with the increased risk of T2DM (OR = 2.53, P = 0.011). In conclusion, besides the consideration of CRP levels alone, the study findings suggested that IL-6 played a contributing role in T2DM progression, and the elevation of TNF-α levels over time could be a potential predictor of T2DM. Moreover, there was a linkage between non-synonymous SNP at codon 196 on TNFRSF1B gene and T2DM development.
Description
Tropical Medicine (Mahidol University 2020)
Degree Name
Doctor of Philosophy
Degree Level
Doctoral Degree
Degree Department
Faculty of Tropical Medicine
Degree Discipline
Tropical Medicine
Degree Grantor(s)
Mahidol University