Increased Prevalence of Gastroesophageal Reflux Disease Among Patients With Rheumatoid Arthritis: A Systematic Review and Meta-analysis
Issued Date
2023-01-01
Resource Type
ISSN
15733971
eISSN
18756360
Scopus ID
2-s2.0-85167668962
Pubmed ID
37066776
Journal Title
Current Rheumatology Reviews
Volume
19
Issue
4
Start Page
496
End Page
503
Rights Holder(s)
SCOPUS
Bibliographic Citation
Current Rheumatology Reviews Vol.19 No.4 (2023) , 496-503
Suggested Citation
Thongpiya J., Charoenngam N., Ponvilawan B., Yingchoncharoen P., Jaroenlapnopparat A., Ungprasert P. Increased Prevalence of Gastroesophageal Reflux Disease Among Patients With Rheumatoid Arthritis: A Systematic Review and Meta-analysis. Current Rheumatology Reviews Vol.19 No.4 (2023) , 496-503. 503. doi:10.2174/1573397119666230414103624 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/89299
Title
Increased Prevalence of Gastroesophageal Reflux Disease Among Patients With Rheumatoid Arthritis: A Systematic Review and Meta-analysis
Author's Affiliation
Other Contributor(s)
Abstract
Objective: This study was conducted to determine the association between gastroesopha-geal reflux disease (GERD) and rheumatoid arthritis (RA) by pooling the evidence from all available studies. Methods: Potentially eligible studies were identified from MEDLINE and EMBASE database from inception to April 2021 employing a search strategy that consisted of terms for “Rheumatoid Arthri-tis” and “Gastroesophageal Reflux Disease”. Eligible studies for the meta-analysis were recruited with conditions of being cohort studies that included rheumatoid arthritis and without rheumatoid arthritis individuals. Together with this, prevalence of GERD in both groups and the odds ratio (OR) comparing the prevalence of GERD between the two cohorts have been reported. The re-trieved point estimates with standard errors from each study were pooled into the final result by the random-effect model and generic inverse variance method as described by DerSimonian and Laird. Results: A total of 3,646 articles were identified. After two rounds of independent review by two investigators, five cohort studies were included in the meta-analysis as they met the eligibility crite-ria. The pooled analysis demonstrated a significant association between RA and GERD with the pooled odds ratio of 1.98 (95% CI, 1.49-2.65). High statistical heterogeneity with I2 of 83% was observed. The funnel plot was symmetric and publication bias was not observed. Conclusion: This systematic review and meta-analysis found a significant association between GERD and RA.