Moving towards high-dose primaquine or single-dose tafenoquine for Plasmodium vivax treatment in Cambodia: a meeting report from dissemination of results of the EFFORT trial to stakeholders
Issued Date
2026-12-01
Resource Type
eISSN
14752875
Scopus ID
2-s2.0-105026502774
Pubmed ID
41484619
Journal Title
Malaria Journal
Volume
25
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Malaria Journal Vol.25 No.1 (2026)
Suggested Citation
Dysoley L., Cassidy-Seyoum S., Adhikari B., Dahal A., Phoumen N., Srey S., Phalla T., Vonn P., Engrkruy B., Sovanarath O., Mengkea H., Rathana P., Makara I., Heng P.K., Heng Y., Khlok H., Pong K., Moeng T., Vantha S., Soviet U., Ravuth R., Bunreth V., Vannak K., Sokhann M., Kimmen K., Dy K., Samol S., Lo K., Sokunthea N., Kry H., Kanha L., Naren L., Oum S., Sovann Y., Channavuth R., Bunmeng C., Hughes J., Brindle H., Hu Y., Peng S., Mardi P., Chanry I., Preap S., Heoy S., Sabawoon F., Sokha T., Ringwald P., Lynch C.A., Price R.N., Tripura R., von Seidlein L., Devine A., Thriemer K. Moving towards high-dose primaquine or single-dose tafenoquine for Plasmodium vivax treatment in Cambodia: a meeting report from dissemination of results of the EFFORT trial to stakeholders. Malaria Journal Vol.25 No.1 (2026). doi:10.1186/s12936-025-05691-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/114715
Title
Moving towards high-dose primaquine or single-dose tafenoquine for Plasmodium vivax treatment in Cambodia: a meeting report from dissemination of results of the EFFORT trial to stakeholders
Author(s)
Dysoley L.
Cassidy-Seyoum S.
Adhikari B.
Dahal A.
Phoumen N.
Srey S.
Phalla T.
Vonn P.
Engrkruy B.
Sovanarath O.
Mengkea H.
Rathana P.
Makara I.
Heng P.K.
Heng Y.
Khlok H.
Pong K.
Moeng T.
Vantha S.
Soviet U.
Ravuth R.
Bunreth V.
Vannak K.
Sokhann M.
Kimmen K.
Dy K.
Samol S.
Lo K.
Sokunthea N.
Kry H.
Kanha L.
Naren L.
Oum S.
Sovann Y.
Channavuth R.
Bunmeng C.
Hughes J.
Brindle H.
Hu Y.
Peng S.
Mardi P.
Chanry I.
Preap S.
Heoy S.
Sabawoon F.
Sokha T.
Ringwald P.
Lynch C.A.
Price R.N.
Tripura R.
von Seidlein L.
Devine A.
Thriemer K.
Cassidy-Seyoum S.
Adhikari B.
Dahal A.
Phoumen N.
Srey S.
Phalla T.
Vonn P.
Engrkruy B.
Sovanarath O.
Mengkea H.
Rathana P.
Makara I.
Heng P.K.
Heng Y.
Khlok H.
Pong K.
Moeng T.
Vantha S.
Soviet U.
Ravuth R.
Bunreth V.
Vannak K.
Sokhann M.
Kimmen K.
Dy K.
Samol S.
Lo K.
Sokunthea N.
Kry H.
Kanha L.
Naren L.
Oum S.
Sovann Y.
Channavuth R.
Bunmeng C.
Hughes J.
Brindle H.
Hu Y.
Peng S.
Mardi P.
Chanry I.
Preap S.
Heoy S.
Sabawoon F.
Sokha T.
Ringwald P.
Lynch C.A.
Price R.N.
Tripura R.
von Seidlein L.
Devine A.
Thriemer K.
Author's Affiliation
Organisation Mondiale de la Santé
Nuffield Department of Medicine
Menzies School of Health Research
Mahidol Oxford Tropical Medicine Research Unit
Centre for Health Policy
Clinton Health Access Initiative, Inc.
Malaria Consortium
National Institute of Public Health Cambodia
MMV Medicines for Malaria Venture
Entomology
Pailin Provincial Health Department
Battambang Provincial Health Department
Catholic Relief Services
Mondulkiri Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
UNOPS
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Abt Global
USAID Global Health Supply Chain Program-Procurement and Supply Management
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Nuffield Department of Medicine
Menzies School of Health Research
Mahidol Oxford Tropical Medicine Research Unit
Centre for Health Policy
Clinton Health Access Initiative, Inc.
Malaria Consortium
National Institute of Public Health Cambodia
MMV Medicines for Malaria Venture
Entomology
Pailin Provincial Health Department
Battambang Provincial Health Department
Catholic Relief Services
Mondulkiri Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
UNOPS
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Abt Global
USAID Global Health Supply Chain Program-Procurement and Supply Management
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Provincial Health Department
Corresponding Author(s)
Other Contributor(s)
Abstract
Cambodia has targeted malaria elimination by 2025. As the malaria burden has decreased in Cambodia, transmission has become more focal, and Plasmodium vivax has become the predominant species. The recurrent nature of P. vivax, due to its dormant liver stages causing relapses, is the main obstacle to malaria elimination in Cambodia. In 2021, Cambodia’s National Center for Parasitology, Entomology and Malaria Control (CNM) rolled out low-dose 14-day primaquine (total dose 3.5 mg/kg) supported by point-of-care quantitative testing for glucose-6-phosphate dehydrogenase deficiency. However, this treatment is limited by poor adherence to its prolonged duration and suboptimal efficacy of the low total dose. The EFFORT clinical trial was conducted in four malaria-endemic countries, including Cambodia, to assess the safety and effectiveness of a 7-day unsupervised high-dose course of primaquine (7 mg/kg total dose) and single dose tafenoquine (300 mg) compared to 14-day unsupervised low-dose primaquine for the treatment of patients presenting with P. vivax malaria. In addition, data were collected on the feasibility and cost-effectiveness of these treatment options. CNM organized the national dissemination of the EFFORT study results on March 27, 2025, to inform key stakeholders and discuss the implications of the study findings for policy and practice in Cambodia.