Effect of sampling paper on dried blood spots specimen collection
2
Issued Date
2013
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Karnrawee Kaewkhao, กานต์รวี แก้วขาว, Tarning, Joel, White, Nicholas J, Blessbron, Daniel (2013). Effect of sampling paper on dried blood spots specimen collection. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/63369
Title
Effect of sampling paper on dried blood spots specimen collection
Abstract
Dried blood spots (DBS) as a sampling technique has been in use for a long time. It is now increasingly
common in preclinical and clinical sample collection especially the studies involving antimalarial
drugs. In the beginning, its purpose was to screen newborn for phenylketonuria. For antimalarial
drugs, it is a simple collection technique, particularly useful in rural areas where resources are limited for
sampling, storage and shipping of venous samples. However, there are several factors to be considered when
using the DBS technique and this poster will describe some of those and what impact it may have on the
final analysis of drug levels in those blood spots. Five different type of filter paper (31ET Chr, FTA DMPK-C,
903 Protein, Ahlstrom 226 and 3MM Chr) were evaluate on paper properties, blood absorption properties
and blood spot distribution, hematocrit and price. The impact on measurement of drug analysis including
influence on storage conditions and drying conditions on DBS sample was investigated.
Description
Joint International Tropical Medicine Meeting 2013: Towards global health: an Asian paradigm of Tropical Medicine 11-13 December 2013 Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2013. p.175-176.