Activation of mast cells in the skin of p. falciparum patients
1
Issued Date
2013
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Panop Wilainam, Rungrat Nintasen, รุ่งรัตน์ นิลธเสน, Polrat Wilairatana, พลรัตน์ วิไลรัตน์, Parnpen Viriyavejakul, พรรณเพ็ญ วิริยเวชกุล (2013). Activation of mast cells in the skin of p. falciparum patients. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/63188
Title
Activation of mast cells in the skin of p. falciparum patients
Abstract
Background: Mast cells (MCs) play an important role in immune and inflammatory processes. MCs can
be stimulated to degranulate and release histamine upon binding to immunoglobulin E (IgE), and
have been linked to IgE-antimalarial antibodies. This study investigated the response of MCs in the skin
of P. falciparum malaria patients.
Methods: The skin tissues of P. falciparum malaria were classified into uncomplicated (10), complicated
(20) malaria and normal skin tissues (29) which served as controls. Tissues from pre- and post-treatment
were included. MCs were investigated by toluidine stain. Other histopathological features evaluated were
extravasation of blood, perivascular edema and leukocyte infiltration. The percentage of MCs degranulation
was compared among groups and correlated with clinical data.
Results: MCs degranulation was seen highest in complicated P. falciparum (44.15% ± 3.20) group as
compared to uncomplicated (33.25% ± 2.99) and control groups (19.84% ± 1.42), (p 0.05). Associated
pathological features including extravasation of blood, perivascular edema, and leukocytic infiltration were
significantly increased between malaria groups and when compared with control group (all p 0.001).
Conclusions: MCs are activated during malaria infection and degree of degranulation is correlated with disease severity.
Description
Joint International Tropical Medicine Meeting 2013: Towards global health: an Asian paradigm of Tropical Medicine 11-13 December 2013 Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2013. p.138.