Synchronous tri-cavitary biphasic malignant mesothelioma in a dog presenting with dyspnea
Issued Date
2023-07-01
Resource Type
ISSN
01256491
Scopus ID
2-s2.0-85197805976
Journal Title
Thai Journal of Veterinary Medicine
Volume
53
Issue
3
Start Page
423
End Page
430
Rights Holder(s)
SCOPUS
Bibliographic Citation
Thai Journal of Veterinary Medicine Vol.53 No.3 (2023) , 423-430
Suggested Citation
Prapaiwan N., Pichayapaiboon P., Ayudhaya T.I.N., Tanglakmankhong O. Synchronous tri-cavitary biphasic malignant mesothelioma in a dog presenting with dyspnea. Thai Journal of Veterinary Medicine Vol.53 No.3 (2023) , 423-430. 430. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/99669
Title
Synchronous tri-cavitary biphasic malignant mesothelioma in a dog presenting with dyspnea
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Malignant mesothelioma is an uncommon tumor that has a challenging diagnosis and a tendency for late diagnosis. A 7-year-old intact male dog presented with respiratory distress. Thoracic radiography revealed pleural effusion and bone reactions at multiple ribs. A computerized tomography scan with rib biopsy was suggested as a diagnosis plan. Unfortunately, the dog died. Gross pathological findings demonstrated multifocal to coalescing, pinkish-white firm masses scattered over the parietal pleural surface, extended to the serosa of the diaphragm and the pericardium, making them adhere to each other and causing the coalescence of a white irregular mass at the diaphragm. Multiple white to pink nodules were also noted at the intercostal muscle, mediastinum, and peritoneum. The histopathologic findings indicated a diffuse nodular structure of neoplasm in the pleura, mediastinum, pericardium, peritoneum, and lungs. The nodules were mainly composed of neoplastic epithelioid cells mixed with a minor component of atypical spindle-shaped cells. A biphasic malignant mesothelioma was considered according to gross appearance, location of lesions, and histopathological findings. The histopathological characteristics of this tumor were confirmed by immunohistochemical staining of vimentin, cytokeratin, and desmin. This report describes the pathomorphological, histopathological, and immunohistochemical features of tri-cavitary biphasic malignant mesothelioma in a dog.