Molecular Testing in Endometrial Cancer: An introduction from basic to practical point
Issued Date
2024-01-01
Resource Type
ISSN
08576084
eISSN
26730871
Scopus ID
2-s2.0-85213284815
Journal Title
Thai Journal of Obstetrics and Gynaecology
Volume
33
Issue
1
Start Page
3
End Page
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Thai Journal of Obstetrics and Gynaecology Vol.33 No.1 (2024) , 3-12
Suggested Citation
Winaitammakul R., Charakorn C. Molecular Testing in Endometrial Cancer: An introduction from basic to practical point. Thai Journal of Obstetrics and Gynaecology Vol.33 No.1 (2024) , 3-12. 12. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/102612
Title
Molecular Testing in Endometrial Cancer: An introduction from basic to practical point
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Author's Affiliation
Corresponding Author(s)
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Abstract
Endometrial cancer exhibits significant molecular heterogeneity, requiring precise classification for optimal management. The current landscape of molecular testing is examined, focusing on the comprehensive The Cancer Genome Atlas (TCGA) classification. This system stratifies endometrial cancers into four subtypes: POLE DNA polymerase epsilon (POLE) ultra-mutated, mismatch repair deficient (dMMR), p53-abnormal, and no specific molecular profile (NSMP). Each subtype’s molecular characteristics, clinical features, and prognostic implications are detailed, including the roles of tumor mutational burden, copy number variation, and key genes such as tumor protein p53 (TP53). Molecular testing algorithms were explored. The clinical implications of each molecular subtype are discussed and emphasized their influence on prognosis and treatment. Simplified, some practical points were linked. Integrating molecular findings with clinicopathological data is highlighted as crucial for personalized patient management.