Gestational diabetes mellitus, not obesity, triggers postpartum brain inflammation and premature aging in Sprague-Dawley rats
Issued Date
2024-11-01
Resource Type
ISSN
03064522
eISSN
18737544
Scopus ID
2-s2.0-85203455919
Pubmed ID
39236804
Journal Title
Neuroscience
Volume
559
Start Page
166
End Page
180
Rights Holder(s)
SCOPUS
Bibliographic Citation
Neuroscience Vol.559 (2024) , 166-180
Suggested Citation
Huang H., Apaijai N., Tun Oo T., Suntornsaratoon P., Charoenphandhu N., Chattipakorn N., Chattipakorn S.C. Gestational diabetes mellitus, not obesity, triggers postpartum brain inflammation and premature aging in Sprague-Dawley rats. Neuroscience Vol.559 (2024) , 166-180. 180. doi:10.1016/j.neuroscience.2024.09.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/101224
Title
Gestational diabetes mellitus, not obesity, triggers postpartum brain inflammation and premature aging in Sprague-Dawley rats
Corresponding Author(s)
Other Contributor(s)
Abstract
Previous studies showed that women with gestational diabetes mellitus (GDM) are susceptible to cognitive dysfunction. We investigated the effects of GDM on brain pathologies and premature brain aging in rats. Seven-week-old female Sprague-Dawley rats were fed a normal diet (ND) or a high-fat diet (HFD) after two weeks of acclimatization. On pregnancy day 0, HFD-treated rats received streptozotocin (GDM group) or vehicle (Obese mothers). ND-treated rats received vehicle (ND-control mothers). On postpartum day 21, brains and blood were collected. The GDM group showed increased inflammatory and premature aging markers, mitochondrial changes, and compensatory increases in the blood–brain barrier and synaptic proteins in the prefrontal cortex and hippocampus. GDM triggers maternal brain inflammation and premature aging, suggesting compensatory mechanisms may protect against these effects.