Expert consensus on gepants for acute and preventive treatment of migraine in Thailand
1
Issued Date
2025-12-01
Resource Type
ISSN
11292369
eISSN
11292377
Scopus ID
2-s2.0-105007432362
Journal Title
Journal of Headache and Pain
Volume
26
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Headache and Pain Vol.26 No.1 (2025)
Suggested Citation
Anukoolwittaya P., Rattanawong W., Vongvaivanich K., Pongpitakmetha T., Thanprasertsuk S., Poonpedpun T., Soontrapa P., Suwanlaong K., Kongbunkiat K., Komonchan S., Dusitanond P., Teekaput C., Sirimaharaj N., Yuvasilp N., Tanprawate S. Expert consensus on gepants for acute and preventive treatment of migraine in Thailand. Journal of Headache and Pain Vol.26 No.1 (2025). doi:10.1186/s10194-025-02074-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110695
Title
Expert consensus on gepants for acute and preventive treatment of migraine in Thailand
Author's Affiliation
Bangkok International Hospital
Songkhla Hospital
The Neurological Society of Thailand (NST)
Rajavej Hospital
Samitivej Hospital (Sukhumvit)
Neurological Institute of Thailand
Bumrungrad International Hospital
Rajavithi Hospital
King Mongkut's Institute of Technology Ladkrabang
Faculty of Medicine, Chulalongkorn University
Siriraj Hospital
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Chiang Mai University
King Chulalongkorn Memorial Hospital
Khon Kaen University
Songkhla Hospital
The Neurological Society of Thailand (NST)
Rajavej Hospital
Samitivej Hospital (Sukhumvit)
Neurological Institute of Thailand
Bumrungrad International Hospital
Rajavithi Hospital
King Mongkut's Institute of Technology Ladkrabang
Faculty of Medicine, Chulalongkorn University
Siriraj Hospital
Faculty of Medicine, Khon Kaen University
Faculty of Medicine, Chiang Mai University
King Chulalongkorn Memorial Hospital
Khon Kaen University
Corresponding Author(s)
Other Contributor(s)
Abstract
Introduction: Gepants, a calcitonin gene-related peptide (CGRP) receptor antagonist, is a class of migraine therapeutic options with extensive evidence supporting a favorable efficacy and safety profile. However, as a novel class of medication in Thailand, specific guidelines or recommendations regarding rational drug use are currently unavailable. This could hinder physicians from utilizing the medications for eligible patients and prevent pharmacists from providing information to physicians and patients. Main body: In order to develop consensus-based statement recommendations, a modified Delphi approach was employed, which included two rounds of surveys, discussions, and voting. General recommendations were made, as well as specific recommendations of gepants in both acute and preventive treatment roles. Additionally, clinical settings where gepants could be suitable options were identified, along with the recommendations for their use in special populations and relevant precautions. Conclusion: Gepants can serve as both acute and preventive therapy for migraines. They provide an alternative to first-line therapies for patients with limitations to conventional agents, including contraindications or intolerance. Gepants can be utilized as monotherapy or in combination with other treatment approaches. Optimal prescribing practices for eligible patients could ensure that patients receive maximum benefit with minimal risk.