Gaps in the Care of Subjects with Familial Hypercholesterolemia: Insights from the Thai Familial Hypercholesterolemia Registry
5
Issued Date
2023-01-01
Resource Type
ISSN
13403478
eISSN
18803873
Scopus ID
2-s2.0-85178659026
Pubmed ID
37197952
Journal Title
Journal of Atherosclerosis and Thrombosis
Volume
30
Issue
12
Start Page
1803
End Page
1816
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Atherosclerosis and Thrombosis Vol.30 No.12 (2023) , 1803-1816
Suggested Citation
Ganokroj P., Muanpetch S., Deerochanawong C., Phimphilai M., Leelawattana R., Thongtang N., Krittayaphong R., Anthanont P., Vathesatogkit P., Sriphrapradang C., Senthong V., Torpongpun A., Suteerayongprasert P., Pengpong N., Sathavarodom N., Sunanta U., Porntharukchareon T., Kiatpanabhikul P., Kaewkrasaesin C., Suraamornkul S., Kongkit J., Umphonsathien M., Chattranukulchai P., Jiamjarasrungsi W., Khovidhunkit W. Gaps in the Care of Subjects with Familial Hypercholesterolemia: Insights from the Thai Familial Hypercholesterolemia Registry. Journal of Atherosclerosis and Thrombosis Vol.30 No.12 (2023) , 1803-1816. 1816. doi:10.5551/jat.64081 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/91517
Title
Gaps in the Care of Subjects with Familial Hypercholesterolemia: Insights from the Thai Familial Hypercholesterolemia Registry
Author(s)
Ganokroj P.
Muanpetch S.
Deerochanawong C.
Phimphilai M.
Leelawattana R.
Thongtang N.
Krittayaphong R.
Anthanont P.
Vathesatogkit P.
Sriphrapradang C.
Senthong V.
Torpongpun A.
Suteerayongprasert P.
Pengpong N.
Sathavarodom N.
Sunanta U.
Porntharukchareon T.
Kiatpanabhikul P.
Kaewkrasaesin C.
Suraamornkul S.
Kongkit J.
Umphonsathien M.
Chattranukulchai P.
Jiamjarasrungsi W.
Khovidhunkit W.
Muanpetch S.
Deerochanawong C.
Phimphilai M.
Leelawattana R.
Thongtang N.
Krittayaphong R.
Anthanont P.
Vathesatogkit P.
Sriphrapradang C.
Senthong V.
Torpongpun A.
Suteerayongprasert P.
Pengpong N.
Sathavarodom N.
Sunanta U.
Porntharukchareon T.
Kiatpanabhikul P.
Kaewkrasaesin C.
Suraamornkul S.
Kongkit J.
Umphonsathien M.
Chattranukulchai P.
Jiamjarasrungsi W.
Khovidhunkit W.
Author's Affiliation
Ramathibodi Hospital
Siriraj Hospital
Chonburi Regional Hospital
Police General Hospital
Bhumibol Adulyadej Hospital
Chulabhorn Royal Academy
King Chulalongkorn Memorial Hospital
Vajira Hospital
Khon Kaen University
Taksin Hospital
Vachira Phuket Hospital
Thammasat University
Charoenkrung Pracharak Hospital
Phramongkutklao College of Medicine
Prince of Songkla University
Rajavithi Hospital
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
King Prajadhipok Memorial Hospital
Siriraj Hospital
Chonburi Regional Hospital
Police General Hospital
Bhumibol Adulyadej Hospital
Chulabhorn Royal Academy
King Chulalongkorn Memorial Hospital
Vajira Hospital
Khon Kaen University
Taksin Hospital
Vachira Phuket Hospital
Thammasat University
Charoenkrung Pracharak Hospital
Phramongkutklao College of Medicine
Prince of Songkla University
Rajavithi Hospital
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
King Prajadhipok Memorial Hospital
Other Contributor(s)
Abstract
Aims: Familial hypercholesterolemia (FH) is currently underdiagnosed and undertreated. The establishment of a FH registry could facilitate a deeper understanding of this disease. We described the clinical characteristics of subjects with FH from the Thai FH Registry, compared our data with the regional and global data, and identified gaps in the care of these subjects. Methods: A multicenter, nationwide prospective FH registry was established in Thailand. Our data were compared with those of the European Atherosclerosis Society-FH Studies Collaboration. Multiple logistic regression analyses were performed for variables associated with lipid-lowering medication (LLM) use and the attainment of low-density lipoprotein-cholesterol (LDL-C) goal. Results: The study includes 472 subjects with FH (mean age at FH diagnosis: 46±12 years, 61.4% women). A history of premature coronary artery disease was found in 12%. The percentage of LLM use in subjects with a Dutch Lipid Clinic Network score of ≥ 6 (probable or definite FH) in our registry (64%) was slightly lower than the regional data but higher than the global data. Among those who received statins, 25.2% and 6.4% achieved LDL-C levels of ＜100 mg/dL and ＜70 mg/dL, respectively. Women with FH were less likely to achieve LDL-C ＜70 mg/dL (adjusted odds ratio: 0.22, 95% confidence interval: 0.06–0.71, p=0.012). Conclusions: FH in Thailand was diagnosed late, and treatment was inadequate for the majority of subjects. Women with FH were less likely to achieve LDL-C goals. Our insights could potentially help raise awareness and narrow the gap in patient care.Clinical Trial Registration Number TCTR20181120001.