Preparation of biocompatible PVA hydrogels as wound dressings by gamma irradiation
2
Issued Date
2022-01-01
Resource Type
Scopus ID
2-s2.0-85147246983
Journal Title
BMEiCON 2022 - 14th Biomedical Engineering International Conference
Rights Holder(s)
SCOPUS
Bibliographic Citation
BMEiCON 2022 - 14th Biomedical Engineering International Conference (2022)
Suggested Citation
Chiangnoon R., Karawak P., Eamsiri J., Thamrongsiripak N., Uttayarat P., Angkhasirisap W., Ampawong S. Preparation of biocompatible PVA hydrogels as wound dressings by gamma irradiation. BMEiCON 2022 - 14th Biomedical Engineering International Conference (2022). doi:10.1109/BMEiCON56653.2022.10012079 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84313
Title
Preparation of biocompatible PVA hydrogels as wound dressings by gamma irradiation
Other Contributor(s)
Abstract
Hydrogels have emerged as a new class of materials that are capable of providing appropriate moist environment for wound healing. In this report, gamma irradiation was utilized to prepare flexible, self-Adhesive, and biocompatible hydrogel sheets from polyvinyl alcohol (PVA) as wound dressings. The PVA concentrations ranged from 6-10 % (w/v) and gamma doses from 10-80 kGy were first varied to optimize the formation of crosslinked, three-dimensional structure of hydrogels. Based on swelling behavior, the 10% (w/v) PVA solution crosslinked at the dose of 40 kGy was selected to fabricate prototypic hydrogel sheets that could conform over skin contour. The extraction-based MTT assay showed that the hydrogel sheets were cytocompatible with L929 cells. When applied on full-Thickness defects in rat model, the hydrogel sheets could facilitate re-epithelization to complete wound closure. These results demonstrate that our PVA hydrogel sheets developed by gamma irradiation can serve as a suitable candidate for wound dressings.