Effectiveness of non-pharmacological intervention protocol for prevention of postoperative delirium in the surgical intensive care unit
11
Issued Date
2025-01-20
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85216439605
Pubmed ID
39833531
Journal Title
Scientific reports
Volume
15
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific reports Vol.15 No.1 (2025) , 2494
Suggested Citation
Yuyen T., Narksut A., Lao-Amornphunkul S., Thanakiattiwibun C., Pansangar C., Thikom N., Chaiwat O., Piriyapatsom A. Effectiveness of non-pharmacological intervention protocol for prevention of postoperative delirium in the surgical intensive care unit. Scientific reports Vol.15 No.1 (2025) , 2494. doi:10.1038/s41598-025-86768-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/104263
Title
Effectiveness of non-pharmacological intervention protocol for prevention of postoperative delirium in the surgical intensive care unit
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Postoperative delirium (POD) is a common adverse event in patients admitted to the intensive care unit (ICU). We aimed to determine the effectiveness of a multicomponent non-pharmacological intervention protocol to reduce the incidence of POD in elderly patients admitted to the surgical ICU (SICU). This before-and-after cohort study included 300 patients aged ≥ 65 years who were admitted to the SICU within 7 days postoperatively with an anticipated SICU stay > 24 h. During the pre-intervention period, patients received medical care based on the attending physicians. While during the intervention, patients received the same medical care plus a multicomponent non-pharmacological intervention protocol. POD was monitored twice daily using the Confusion Assessment Method for the ICU. Demographic and clinical data during SICU stay were collected and compared between the pre-intervention and intervention periods. The primary outcome was POD incidence. The secondary outcomes were POD duration, delirium-free days, and other clinical outcomes. The incidences of POD during the pre-intervention and intervention periods were not different (40.0% vs. 38.0%, P = 0.723; OR 0.92, 95% CI 0.58-1.46). Multivariate regression analyses with two different models demonstrated that the multicomponent non-pharmacological intervention protocol was not associated with POD prevention (OR 0.70, 95% CI 0.39-1.25 for Model 1 and OR 0.63, 95% CI 0.37-1.08 for Model 2). The protocol was associated with lower incidence of SICU events, particularly self-removal of endotracheal tube and nosocomial infection. Implementation of the multicomponent non-pharmacological intervention protocol was not associated with POD prevention in elderly patients admitted to the SICU.Trial registration Thai Clinical Trials Registry. Trial No. TCTR20181201001. Retrospective registered 01 December 2018.