The proportion of Thai postmenopausal women who would be eligible for anti-osteoporosis therapy
2
Issued Date
2023-02-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85147457530
Pubmed ID
36735672
Journal Title
PLoS ONE
Volume
18
Issue
2 February
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS ONE Vol.18 No.2 February (2023)
Suggested Citation
Chanidkul P., Sribenjalak D., Charoenngam N., Pongchaiyakul C. The proportion of Thai postmenopausal women who would be eligible for anti-osteoporosis therapy. PLoS ONE Vol.18 No.2 February (2023). doi:10.1371/journal.pone.0279829 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82154
Title
The proportion of Thai postmenopausal women who would be eligible for anti-osteoporosis therapy
Author's Affiliation
Other Contributor(s)
Abstract
Purpose To determine the proportion of postmenopausal Thai women who would be classified as having high risk of fracture and eligible for anti-osteoporosis therapy according to the National Osteoporosis Foundation (NOF) criteria. Methods Postmenopausal Thai women aged 40–90 years who had been screened for osteoporosis during 2014–2019 were recruited. Demographic data and osteoporosis risk factors were collected based on the Fracture Risk Assessment Tool (FRAX) questionnaire. Bone mineral density (BMD) at the femoral neck and lumbar spine measured using dual energy X-ray absorptiometry. Ten-year probabilities of hip and major osteoporotic fracture (MOF) were calculated based on the Thai FRAX model with BMD. The study’s protocol was approved by the Institutional Ethical Committee (HE581241). Results A total of 3,280 postmenopausal women were included. The mean ± SD age was 63.6 ± 10.1 years. A total of 170 (5.2%) participants had a history of hip and/or vertebral fracture. After excluding these participants with fracture history, 699 (21.3%) had osteoporosis, 355 (10.8%) had osteopenia with high risk of fracture (FRAX 10-year probability of hip fracture ≥ 3% and/or MOF ≥ 20%), 1192 (36.3%) had osteopenia with low risk of fracture (FRAX 10-year probability of hip fracture < 3% and MOF < 20%) and 864 (26.3%) had normal BMD. Taken together, a total of 1,224 (37.3%) participants would be eligible for anti-osteoporosis therapy (prior fracture, osteoporosis or osteopenia with high risk of fracture). Conclusion The prevalence of Thai postmenopausal women who would be eligible for anti-osteoporosis therapy was 37.3%.