Emergency myelopoiesis in solid cancers
Issued Date
2024-01-01
Resource Type
ISSN
00071048
eISSN
13652141
Scopus ID
2-s2.0-85199378508
Pubmed ID
39044285
Journal Title
British Journal of Haematology
Rights Holder(s)
SCOPUS
Bibliographic Citation
British Journal of Haematology (2024)
Suggested Citation
Aliazis K., Yenyuwadee S., Phikulsod P., Boussiotis V.A. Emergency myelopoiesis in solid cancers. British Journal of Haematology (2024). doi:10.1111/bjh.19656 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100072
Title
Emergency myelopoiesis in solid cancers
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Author's Affiliation
Corresponding Author(s)
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Abstract
Cells of the innate and adaptive immune systems are the progeny of haematopoietic stem and progenitor cells (HSPCs). During steady-state myelopoiesis, HSPC undergo differentiation and proliferation but are called to respond directly and acutely to various signals that lead to emergency myelopoiesis, including bone marrow ablation, infections, and sterile inflammation. There is extensive evidence that many solid tumours have the potential to secrete classical myelopoiesis-promoting growth factors and other products able to mimic emergency haematopoiesis, and to aberrantly re-direct myeloid cell development into immunosuppressive cells with tumour promoting properties. Here, we summarize the current literature regarding the effects of solid cancers on HSPCs function and discuss how these effects might shape antitumour responses via a mechanism initiated at a site distal from the tumour microenvironment.