Obesity classified by anthropometric parameters was associated with mitochondrial bioenergetics impairment of peripheral blood mononuclear cells in the elderly population
Issued Date
2025-04-01
Resource Type
ISSN
05315565
eISSN
18736815
Scopus ID
2-s2.0-85219452626
Journal Title
Experimental Gerontology
Volume
202
Rights Holder(s)
SCOPUS
Bibliographic Citation
Experimental Gerontology Vol.202 (2025)
Suggested Citation
Attachaipanich T., Sriwichaiin S., Apaijai N., Thanyaratsarun T., Thongmung N., Vathesatogkit P., Sritara P., Chattipakorn N., Kitiyakara C., Chattipakorn S.C. Obesity classified by anthropometric parameters was associated with mitochondrial bioenergetics impairment of peripheral blood mononuclear cells in the elderly population. Experimental Gerontology Vol.202 (2025). doi:10.1016/j.exger.2025.112724 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/105608
Title
Obesity classified by anthropometric parameters was associated with mitochondrial bioenergetics impairment of peripheral blood mononuclear cells in the elderly population
Corresponding Author(s)
Other Contributor(s)
Abstract
Waist circumference (WC), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR), even in individuals who have a normal body mass index (BMI), are correlated with cardiovascular events. The aim of this study is to establish the association between obesity and mitochondrial bioenergetics in peripheral blood mononuclear cells (PBMCs). The study included 1584 subjects from the Electricity Generating Authority of Thailand (EGAT) cohort. The mean age of participants in this study was 68.4 years. There was 24.2 % diabetes mellitus (DM) with a mean HbA1c level of 6.8. WC, WHR, and WHtR were associated with decreased basal, maximal respiration, spare respiratory capacity (SRC), and ATP production, whereas BMI was only associated with reduced maximal respiration and SRC. We further stratified the participants into four groups based on obesity classified by WHR and DM status: Non-DM/Non-obese (n = 468), Non-DM/Obese (n = 733), DM/Non-obese (n = 84), and DM/Obese (n = 299). Both obesity and DM were associated with mitochondrial bioenergetic impairment and increased mitochondrial oxidative stress. Interestingly, there was no difference in mitochondrial bioenergetics impairment between non-DM/Obese and DM participants. Our study demonstrated that WC, WHR, and WHtR better reflected underlying mitochondrial dysfunction in PBMCs compared to BMI. Furthermore, obesity was associated with mitochondrial dysfunction to the same degree as DM.