The effects of adhesives on properties of ketoprofen patches

Abstract

Transdermal drug delivery system of ketoprofen was developed in this study. The aim of this study was to develop the transdermal drug delivery system that can reduce gastric irritation, dosing frequency and thus improve patient compliance. Ketoprofen patch was prepared by using acrylic as adhesive polymer matrix, mixture of ethanol as vehicle and Panasate 800 as enhancer in 50:50% w/w with 10%w/w of ketoprofen. The effects of class of acrylic adhesive (Duro-Tak® 87-2516, Duro-Tak® 87-2852 and Duro-Tak® 87-4098) and the concentration of acrylic adhesive (30%, 40% and 50% w/w) on skin permeation using human skin and adhesive properties were investigated. The results showed that the class of acrylic adhesive did not affect skin permeation but the adhesive properties by Duro-Tak® 87-2852 contained the highest peel and tack properties, followed by Duro-Tak® 87-2516 and Duro-Tak® 87- 4098 respectively. In addition, the skin permeation of the ketoprofen patches decreased when the concentration of acrylic adhesives increased. The same results were also found in adhesive properties, where peel and tack decreased when the concentration of acrylic adhesive increased. The drug permeation profile of ketoprofen from the patches followed Fick's equation, which indicated partition control. The results of this study indicated that the ketoprofen patch with 40% w/w of Duro-Tak® 87-2852 was the best formula. Compared with the commercial topical gel, this formula (B2) showed a higher permeation rate, however, the flux of drug permeation is lower composed with that theoretically indicated.