Whey protein positively alters inflammatory markers and metabolic parameters of overweight and obese adults
3
Issued Date
2022-01-01
Resource Type
ISSN
1394035X
Scopus ID
2-s2.0-85146274007
Journal Title
Malaysian Journal of Nutrition
Volume
28
Issue
3
Start Page
369
End Page
382
Rights Holder(s)
SCOPUS
Bibliographic Citation
Malaysian Journal of Nutrition Vol.28 No.3 (2022) , 369-382
Suggested Citation
Phosat C., Phosat C., Hudthagosol C., Phienluphon P.P., Kwanbunjan K. Whey protein positively alters inflammatory markers and metabolic parameters of overweight and obese adults. Malaysian Journal of Nutrition Vol.28 No.3 (2022) , 369-382. 382. doi:10.31246/mjn-2021-0100 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83350
Title
Whey protein positively alters inflammatory markers and metabolic parameters of overweight and obese adults
Other Contributor(s)
Abstract
Introduction: The effects of prolonged consumption of whey protein on health are controversial. This study aimed to determine whether whey protein positively alters health parameters of overweight and obese adults. Methods: Randomised controlled trial was conducted. Fifty-eight participants, aged 30-50 years, were randomly allocated into four groups and supplemented with 50 g protein for eight weeks (group 1: plant-based protein (PBP), group 2: whey protein isolate (WPI) with cocoa powder, group 3: PBP with whey protein concentrate (WPC), and group 4: WPI with milk powder). Body composition and biochemical parameters (kidney and liver functions, inflammation, oxidative stress, and antioxidant capacity) were evaluated at pre-intervention and 8 weeks after intervention. Results: At Week 8, group 3 had lower diastolic blood pressure, waist circumference, visceral fat, and risk of insulin resistance (p<0.05 for all). Group 2 had decreased levels of total cholesterol and low-density lipoprotein cholesterol (p<0.05 for all). A drop in triglyceride was seen in group 4 (p=0.026). Whey protein decreased alanine aminotransferase level (p=0.028), while PBP increased aspartate aminotransferase level (p=0.034). PBP or WPI with milk powder increased blood urea nitrogen level (p>0.05 for all). Interleukin-6 and lactoferrin levels fell in all groups (p<0.05), while hs-CRP increased in the PBP group (p=0.043). Group 2 experienced increased antioxidant capacity. However, levels of oxidative stress markers were significantly decreased in the PBP group and WPI with milk powder group. Conclusion: Whey protein revealed positive effects on anthropometric parameters and biochemical markers of overweight and obese adults. Therefore, proper supplementation of whey protein can potentially promote health.