Potential association of blood monocyte phenotypes and pathology in plasmodium vivax infection
Issued Date
2014
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Pattamawan Chimma, Panudda Sratongno, Christian Roussilhon, Anavaj Sakuntabhai, Srivicha Krudsood, ศรีวิชา ครุฑสูตร, Jarinee Tongshob, จารินี ทองชุบ, Warunya Woradulayapinij, Srisin Khusmith, ศรีสิน คูสมิทธิ์ (2014). Potential association of blood monocyte phenotypes and pathology in plasmodium vivax infection. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/63158
Title
Potential association of blood monocyte phenotypes and pathology in plasmodium vivax infection
Abstract
Monocyte subpopulations display distinct phenotypes and functions
which can drastically change during inflammatory states. Recently,
the increased number of a pro-inflammatory monocytes subpopulation
(CD14loCD16hi) during P. falciparum infection was observed, with remarkable levels of
CX3CR1, HLA-DR, TREM-1 and CD56 presented in this monocyte subset. However,
the role of human blood monocytes in vivax malaria has never been explored.
This study aimed to determine any potential association between blood monocyte
phenotypes and clinical manifestation in patients with P. vivax infection. Monocyte
phenotypes were characterized by immunophenotyping, followed by FACSCalibur, the
4 colors detected cytometer. The investigation was performed as a blind study. The
result showed that on admission (D0), both percentage and absolute number of blood
monocytes in patients with P. vivax infection are significantly increased (p= 0.0033 and
p=0.0073, respectively). Interestingly, the numbers of CX3CR1+CD14loCD16hi blood
monocytes are different among the 3 groups of thrombocytopenic patients with severe,
moderate and mild thrombocytopenia, which is associated with blood platelet levels. In
addition, a positive correlation between CX3CR1+CD14loCD16hi blood monocytes and
percentage of hematocrit was observed (r=0.3168, p=0.0436). The results suggested
that CX3CR1+CD14loCD16hi blood monocytes are induced during P. vivax infection,
which may associate with pathology of the disease.
Description
Joint International Tropical Medicine Meeting 2014: 3D perspectives on tropical medicine: drivers, diversity and determination the 8th seminar on food-and water-borne parasitic zoonoses: 2-4 December 2014: Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2014. p. 225.
