Incidence of acute liver failure and its associated mortality in patients with dengue infection: A systematic review and meta-analysis
Issued Date
2024-08-01
Resource Type
ISSN
18760341
eISSN
1876035X
Scopus ID
2-s2.0-85198744530
Journal Title
Journal of Infection and Public Health
Volume
17
Issue
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infection and Public Health Vol.17 No.8 (2024)
Suggested Citation
Wongtrakul W., Charatcharoenwitthaya K., Karaketklang K., Charatcharoenwitthaya P. Incidence of acute liver failure and its associated mortality in patients with dengue infection: A systematic review and meta-analysis. Journal of Infection and Public Health Vol.17 No.8 (2024). doi:10.1016/j.jiph.2024.102497 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/99786
Title
Incidence of acute liver failure and its associated mortality in patients with dengue infection: A systematic review and meta-analysis
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Abstract
Acute liver failure (ALF) is a devastating consequence of dengue infection. This systematic review and meta-analysis assessed the incidence of ALF in dengue infection and its associated mortality. We systematically searched the EMBASE and MEDLINE databases from inception to December 2023 for observational studies reporting ALF incidence and mortality in dengue patients. Twenty-one studies encompassing 26,839 dengue-infected patients were included. Meta-analysis revealed a pooled incidence of ALF in cases of general dengue infection of 2.0 % (95 % CI, 1.2–3.0 %), with 1.2 % (95 % CI, 0.6–2.1 %) in adults and 5.0 % (95 % CI, 1.5–10.2 %) in children. ALF incidence was 17.3 % (95 % CI, 6.5 %−31.5 %) in severe dengue and 7.4 % (95 % CI, 0.8–18.5 %) in dengue shock syndrome. The pooled mortality rate of dengue-associated ALF was 47.0 % (95 % CI, 32.9–61.2 %). These findings underscore the detrimental impact of dengue infection on the development of the relatively uncommon, albeit life-threatening, condition of ALF.