The triple burden of sex disparities in critical care mechanical ventilation
Issued Date
2026-05-01
Resource Type
ISSN
00070912
eISSN
14716771
Scopus ID
2-s2.0-105036665466
Pubmed ID
41786545
Journal Title
British Journal of Anaesthesia
Volume
136
Issue
5
Start Page
1431
End Page
1435
Rights Holder(s)
SCOPUS
Bibliographic Citation
British Journal of Anaesthesia Vol.136 No.5 (2026) , 1431-1435
Suggested Citation
Schultz M.J., Tschernko E., Modra L.J., Eberl S. The triple burden of sex disparities in critical care mechanical ventilation. British Journal of Anaesthesia Vol.136 No.5 (2026) , 1431-1435. 1435. doi:10.1016/j.bja.2026.02.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116477
Title
The triple burden of sex disparities in critical care mechanical ventilation
Author(s)
Corresponding Author(s)
Other Contributor(s)
Abstract
Females with acute respiratory distress syndrome (ARDS) face disproportionate harm from mechanical ventilation because of smaller functional lung volumes. This biological vulnerability demands sex-specific approaches. Yet disparities extend beyond physiology. Predicted bodyweight formulas systematically overestimate lung capacity in females, creating algorithmic bias linked to mortality. Females receive less aggressive treatment for ARDS than men but achieve similar survival, suggesting either resilience in women or overtreatment in men. Critical care research underrepresents females and rarely performs sex-disaggregated analyses. Addressing these interconnected problems requires refining clinical protocols, mandating sex-stratified trial analyses, and auditing treatment patterns to distinguish appropriate individualisation from bias.