Asian–Pacific perspectives on the management of very early-onset inflammatory bowel disease
Issued Date
2025-10-01
Resource Type
ISSN
15989100
eISSN
22881956
Scopus ID
2-s2.0-105019970091
Journal Title
Intestinal Research
Volume
23
Issue
4
Start Page
405
End Page
429
Rights Holder(s)
SCOPUS
Bibliographic Citation
Intestinal Research Vol.23 No.4 (2025) , 405-429
Suggested Citation
Takeuchi I., Arai K., Tanpowpong P., Lai M.W., Day A.S., Lee W.S., Huang J.G., Calixto-Mercado K.S., Wong R.M.S., Alvi M.A., Grover Z., Shim J.O., Poddar U. Asian–Pacific perspectives on the management of very early-onset inflammatory bowel disease. Intestinal Research Vol.23 No.4 (2025) , 405-429. 429. doi:10.5217/ir.2025.00082 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112889
Title
Asian–Pacific perspectives on the management of very early-onset inflammatory bowel disease
Author's Affiliation
Chang Gung Memorial Hospital
Seoul National University College of Medicine
NUS Yong Loo Lin School of Medicine
Chang Gung University College of Medicine
National University Hospital
Sanjay Gandhi Postgraduate Institute of Medical Sciences
University of Otago, Christchurch
Universiti Tunku Abdul Rahman
National Center for Child Health and Development
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Perth Children's Hospital
Hong Kong Children's Hospital
Makati Medical Center
The Medical City
University of Child Health Sciences
Philippine Children’s Medical Center
Seoul National University College of Medicine
NUS Yong Loo Lin School of Medicine
Chang Gung University College of Medicine
National University Hospital
Sanjay Gandhi Postgraduate Institute of Medical Sciences
University of Otago, Christchurch
Universiti Tunku Abdul Rahman
National Center for Child Health and Development
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Perth Children's Hospital
Hong Kong Children's Hospital
Makati Medical Center
The Medical City
University of Child Health Sciences
Philippine Children’s Medical Center
Corresponding Author(s)
Other Contributor(s)
Abstract
Children diagnosed with inflammatory bowel disease (IBD) before the age of 6 years are considered to have “very early-onset IBD (VEO-IBD),” which is challenging to diagnose and treat. Notably, many children with VEO-IBD have monogenic forms of the disease, meaning that early genetic testing is useful. However, because the prevalence of genetic variants causing VEO-IBD differs globally, the diagnosis and treatment of this disease should be tailored to each region. In the present review paper, the IBD Subcommittee of the Scientific Committee of the Asia-Pacific Society of Pediatric Gastroenterology, Hepatology and Nutrition (APSPGHAN) has summarized the epidemiology, presenting features, diagnosis, and treatment of VEO-IBD in the Asia–Pacific region, with an aim to guide clinicians and researchers who work with VEO-IBD in this area. Our 3 main messages are as follows: endoscopy is essential for VEO-IBD diagnosis; all children diagnosed with VEO-IBD should be suspected of having a monogenic form; and children with suspected monogenic IBD should undergo early genetic testing. Our messages aim to improve the early diagnosis and treatment of VEO-IBD in the Asia–Pacific region, including the early detection of monogenic IBD in this area.