Chromosomal abnormalities study for anembryonic pregnancy by BACs-on-Beads technique
Issued Date
2024-07-01
Resource Type
ISSN
03012115
eISSN
18727654
Scopus ID
2-s2.0-85192385872
Pubmed ID
38705011
Journal Title
European Journal of Obstetrics and Gynecology and Reproductive Biology
Volume
298
Start Page
31
End Page
34
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Obstetrics and Gynecology and Reproductive Biology Vol.298 (2024) , 31-34
Suggested Citation
Onsod P., Jaranasaksakul W., Chareonsirisuthigul T., Parinayok R., Rerkamnuaychoke B., Areesirisuk P. Chromosomal abnormalities study for anembryonic pregnancy by BACs-on-Beads technique. European Journal of Obstetrics and Gynecology and Reproductive Biology Vol.298 (2024) , 31-34. 34. doi:10.1016/j.ejogrb.2024.04.041 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98342
Title
Chromosomal abnormalities study for anembryonic pregnancy by BACs-on-Beads technique
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Abstract
Objective: This study evaluated the BACs-on-Beads™ (BoBs) efficiency assay in detecting chromosomal anomalies in products of conception (POC) specimens associated with anembryonic pregnancy (AP) among Thai pregnant women. Method: Retrospective analysis applied the BoBs™ assay to examine AP samples from 2010 to 2022. The incidences of AP with chromosomal abnormalities were reported. Result: Assessment of villi from anembryonic pregnancy samples found normal chromosome complement in 50% of the cases, while the remainder showed chromosomal abnormalities. Trisomy 16 was found in 15% of the cases and trisomies 22, 15, and 19 in 9.6%, 3.8%, and 3.8%, respectively. Advanced maternal age was associated with a higher incidence of aneuploidy. Conclusion: The BoBs™ assay effectively detected diverse chromosomal abnormalities in villi samples from POC. The diagnostic utility of the BoBs™ assay was highlighted in identifying chromosomal irregularities in AP cases. Trisomy 16 possessed the most chromosomal abnormalities in the AP samples.