Efficacy and Safety of Clinacanthus nutans Lindau Cream vs. Podophyllin for the Treatment of Adults with Condyloma Acuminata
Issued Date
2022-01-01
Resource Type
ISSN
1741427X
eISSN
17414288
Scopus ID
2-s2.0-85145813290
Journal Title
Evidence-based Complementary and Alternative Medicine
Volume
2022
Rights Holder(s)
SCOPUS
Bibliographic Citation
Evidence-based Complementary and Alternative Medicine Vol.2022 (2022)
Suggested Citation
Jiamton S. Efficacy and Safety of Clinacanthus nutans Lindau Cream vs. Podophyllin for the Treatment of Adults with Condyloma Acuminata. Evidence-based Complementary and Alternative Medicine Vol.2022 (2022). doi:10.1155/2022/1577716 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86222
Title
Efficacy and Safety of Clinacanthus nutans Lindau Cream vs. Podophyllin for the Treatment of Adults with Condyloma Acuminata
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Human papillomavirus (HPV) infection causes condyloma acuminata (CA). Podophyllin is the standard treatment. Clinacanthus nutans Lindau (C. nutans), a medicinal plant, has potent anti-inflammatory and antiviral effects. C. nutans cream is widely used in Thailand to treat the herpes simplex virus. We proposed that C. nutans might also induce CA clearance. There are no studies of C. nutans treatment of CA. This randomized controlled trial at Siriraj Hospital, Thailand, was conducted between January 2018 and December 2019. CA samples were obtained from 10 men with at least two CAs 1 centimeter apart. Each wart was randomized to a 4-week treatment with either C. nutans or podophyllin. The participants were 24 to 72 years old. Most HPV types were low-risk HPVs (HPV 11, HPV 6). Median CA clearance with podophyllin was a 97% CA clearance with podophyllin and 82% with C. nutans. C. nutans may be an alternative treatment for CA.