Phenolic content of Thai Bao mango peel and its in-vitro antioxidant, anti-cholinesterase, and antidiabetic activities
Issued Date
2024-08-01
Resource Type
ISSN
1319562X
Scopus ID
2-s2.0-85195057656
Journal Title
Saudi Journal of Biological Sciences
Volume
31
Issue
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
Saudi Journal of Biological Sciences Vol.31 No.8 (2024)
Suggested Citation
Thangsiri S., Suttisansanee U., Koirala P., Chathiran W., Srichamnong W., Li L., Nirmal N. Phenolic content of Thai Bao mango peel and its in-vitro antioxidant, anti-cholinesterase, and antidiabetic activities. Saudi Journal of Biological Sciences Vol.31 No.8 (2024). doi:10.1016/j.sjbs.2024.104033 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98701
Title
Phenolic content of Thai Bao mango peel and its in-vitro antioxidant, anti-cholinesterase, and antidiabetic activities
Author's Affiliation
Corresponding Author(s)
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Abstract
Plant phenolics have been known for various biological activities. This study aims to extract and examine the presence of phenolics in Bao mango (Mangifera indica L. var.) peel ethanolic extract (MPE). Further, antioxidant, anti-diabetic (α-amylase, and α-glucosidase inhibitory activity), and anti- Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase (BACE-1) inhibitory activity) efficacy of MPE were determined. The results indicated that mangiferin (8755.89 mg/ 100 g extract) was the major phenolic compound in MPE. An antioxidant mechanism revealed that MPE had a higher radical scavenging ability (4266.70 µmol TE/g extract) compared to reducing power (FRAP) or oxygen radical absorption capacity (ORAC). Further in-vitro enzyme inhibitory assay against diabetic and AD involved enzymes showed that MPE had stronger inhibitory action against an enzyme involved in diabetes compared to their standard drug (Acarbose) (P < 0.05). While a lower IC50 value was observed against AD-involved enzymes compared to their standard drug (donepezil) (P < 0.05). The results show that Thai Bao mango peel byproduct can be a potential source of nutraceuticals to lower diabetes and improve cognitive health.