Ethnicity-specific associations between the promoter region G-308A polymorphism (rs1800629) of the TNF-α gene and the development of end-stage renal disease: An evidence-based meta-analysis and trial sequential analysis
Issued Date
2025-01-01
Resource Type
ISSN
14154757
eISSN
16784685
Scopus ID
2-s2.0-86000082324
Journal Title
Genetics and Molecular Biology
Volume
48
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Genetics and Molecular Biology Vol.48 No.1 (2025)
Suggested Citation
Anumas S., Tansawet A., Numthavaj P., Pattharanitima P., Pabalan N., Jarjanazi H., Mongkolrob R., Tasanarong A., Tharabenjasin P. Ethnicity-specific associations between the promoter region G-308A polymorphism (rs1800629) of the TNF-α gene and the development of end-stage renal disease: An evidence-based meta-analysis and trial sequential analysis. Genetics and Molecular Biology Vol.48 No.1 (2025). doi:10.1590/1678-4685-GMB-2024-0077 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/106698
Title
Ethnicity-specific associations between the promoter region G-308A polymorphism (rs1800629) of the TNF-α gene and the development of end-stage renal disease: An evidence-based meta-analysis and trial sequential analysis
Corresponding Author(s)
Other Contributor(s)
Abstract
Tumor necrosis factor-alpha (TNF-α), is partly attributed to pathogenesis of end-stage renal disease (ESRD). Inconsistency of reported associations between TNF-α G-308A polymorphism (rs1800629) and ESRD prompted a meta-analysis to obtain more precise estimates. Eleven case-control studies from 11 articles were included. Pooled odds ratios (OR) and 95% confidence intervals (95% CIs) were estimated to evaluate the association. Subgroup analysis was based on ethnicity (Caucasian and Asian). Multiple comparisons were Bonferroni-corrected. Trial sequential analysis (TSA) was implemented to ascertain the reliability of results. Sensitivity analyses and publication bias tests were performed on significant results. There were no significant association (pa >0.05) in the overall and ethnic subgroup. Indians, three significant pool ORs (pa < 0.01-0.03) showed increased susceptibility to ESRD in homozygous (OR, 6.57; 95% CI, 1.45 to 29.75; pa = 0.01), recessive (OR, 6.75; 95% CI, 1.44 to 31.56; pa = 0.02), and codominant (OR, 2.06; 95% CI, 1.08 to 3.94; pa = 0.03) models. TSA indicated the robustness of such association in the Indian population. The main outcomes were robust without evidence of publication bias. This study showed associations between TNF-α G-308A and ESRD are confined to Indians, which are susceptible to ESRD up to approximately 7 times.