The Association of HLA-B*35 and GSTT1 Genotypes and Hepatotoxicity in Thai People Living with HIV
Issued Date
2022-06-01
Resource Type
eISSN
20754426
Scopus ID
2-s2.0-85132189001
Journal Title
Journal of Personalized Medicine
Volume
12
Issue
6
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Personalized Medicine Vol.12 No.6 (2022)
Suggested Citation
Chanhom N., Jittikoon J., Wattanapokayakit S., Mahasirimongkol S., Charoenyingwattana A., Udomsinprasert W., Chaikledkaew U., Suvichapanich S., Mushiroda T., Kiertiburanakul S., Rojanawiwat A., Wangsomboonsiri W., Manosuthi W., Kantipong P., Apisarnthanarak A., Sangsirinakakul W., Wongprasit P., Chaiwarith R., Tantisiriwat W., Sungkanuparph S., Chantratita W. The Association of HLA-B*35 and GSTT1 Genotypes and Hepatotoxicity in Thai People Living with HIV. Journal of Personalized Medicine Vol.12 No.6 (2022). doi:10.3390/jpm12060940 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85812
Title
The Association of HLA-B*35 and GSTT1 Genotypes and Hepatotoxicity in Thai People Living with HIV
Author(s)
Chanhom N.
Jittikoon J.
Wattanapokayakit S.
Mahasirimongkol S.
Charoenyingwattana A.
Udomsinprasert W.
Chaikledkaew U.
Suvichapanich S.
Mushiroda T.
Kiertiburanakul S.
Rojanawiwat A.
Wangsomboonsiri W.
Manosuthi W.
Kantipong P.
Apisarnthanarak A.
Sangsirinakakul W.
Wongprasit P.
Chaiwarith R.
Tantisiriwat W.
Sungkanuparph S.
Chantratita W.
Jittikoon J.
Wattanapokayakit S.
Mahasirimongkol S.
Charoenyingwattana A.
Udomsinprasert W.
Chaikledkaew U.
Suvichapanich S.
Mushiroda T.
Kiertiburanakul S.
Rojanawiwat A.
Wangsomboonsiri W.
Manosuthi W.
Kantipong P.
Apisarnthanarak A.
Sangsirinakakul W.
Wongprasit P.
Chaiwarith R.
Tantisiriwat W.
Sungkanuparph S.
Chantratita W.
Author's Affiliation
RIKEN Center for Integrative Medical Sciences
Faculty of Medicine, Chiang Mai University
Thammasat University Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Thailand Ministry of Public Health
Mahidol University
Sawanpracharak Hospital
Faculty of Medicine, Srinakharinwirot University
Buriram Hospital
Maharaj Nakornratchasima Hospital
Bamrasnaradura Infectious Diseases Institute
Chiangrai Prachanukroh Hospital
Faculty of Medicine, Chiang Mai University
Thammasat University Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Thailand Ministry of Public Health
Mahidol University
Sawanpracharak Hospital
Faculty of Medicine, Srinakharinwirot University
Buriram Hospital
Maharaj Nakornratchasima Hospital
Bamrasnaradura Infectious Diseases Institute
Chiangrai Prachanukroh Hospital
Other Contributor(s)
Abstract
Glutathione s-transferase (GST) is a family of drug-metabolizing enzymes responsible for metabolizing and detoxifying drugs and xenobiotic substances. Therefore, deletion polymorphisms of GSTs can be implicated in developing several pathological conditions, including antiretroviral druginduced liver injury (ARVDILI). Notably, GST polymorphisms have been shown to be associated with ARVDILI risk. However, data on GST polymorphisms in the Thai population are limited. Therefore, this study investigated possible associations between GST genetic polymorphisms and ARVDILI development. A total of 362 people living with HIV (PLHIV) and 85 healthy controls from multiple centers were enrolled. GSTM1 and GSTT1 genetic polymorphisms were determined using polymerase chain reactions. In addition, HLA genotypes were determined using a sequence-based HLA typing method. After comparing GST genotypic frequencies, there was no significant difference between PLHIV and healthy volunteers. However, while observing the PLHIV group, GSTT1 wild type was significantly associated with a 2.04-fold increased risk of ARVDILI (95%CI: 1.01, 4.14; p = 0.045). Interestingly, a combination of GSTT1 wild type and HLA-B*35:05 was associated with a 2.28-fold higher risk of ARVDILI (95%CI: 1.15, 4.50; p = 0.02). Collectively, GSTT1 wild type and a combination of GSTT1 wild type plus HLA-B*35:05 were associated with susceptibility to ARVDILI in the Thai population.