The in vitro effects of dengue-2 virus on the platelets in normal subjects
1
Issued Date
1990
Copyright Date
1990
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
viii, 62 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Pharmacology))--Mahidol University, 1990
Suggested Citation
Narumon Laohareungpanya The in vitro effects of dengue-2 virus on the platelets in normal subjects. Thesis (M.Sc. (Pharmacology))--Mahidol University, 1990. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/103319
Title
The in vitro effects of dengue-2 virus on the platelets in normal subjects
Alternative Title(s)
การศึกษาผลของไวรัส เดงกี่-2 ที่มีต่อเกร็ดเลือดของคนปรกติในหลอดทดลอง
Author(s)
Advisor(s)
Abstract
Thrombocytopenia is a constant finding in DHf/Dss. The mechanisms leading to thrombocytopenia is still not clearly understood. Although many mechanisms have been proposed, the massive disappearance of platelets from the circulation and the concurrent homeostasis adaptation of various blood components including those circulating cells caused limitation to the understanding how dengue virus affected platelets in the studies that performed in the patients. This study was designed to clarify the direct effect of dengue virus on the changes that occurred in the platelets. The mechanisms leading to the defects have also been studied by using antithrombotic agents as aspirin and heparin. The interaction of dengue-2 virus with the normal platelets were found to induce both the abnormal platelet functions as assayed by the increase response to low dose of ADP(2um) and the loss in platelet number by the dengue virus in vitro. The change in platelet number was found after the changes in platelet function. these effects were not found in anti-complement dose heparin (25u/c.c) and they were cyclo-oxygenase dependent. These would sug-gest that the thrombocytopenia is probably due to the mild pro-aggregatory properties of dengue viruses and the complement factor might be one of the causes that requires further clarification.
Description
Pharmacology (Mahidol University 1990)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Pharmacology
Degree Grantor(s)
Mahidol University