Comparing the Time of Passage of the First Meconium (PoFM) in Neonates With and Without Hirschsprung’s Disease (HD)
4
Issued Date
2025-04-01
Resource Type
ISSN
01252208
Scopus ID
2-s2.0-105007460483
Journal Title
Journal of the Medical Association of Thailand
Volume
108
Issue
4
Start Page
283
End Page
288
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand Vol.108 No.4 (2025) , 283-288
Suggested Citation
Ruangtrakool R., Boonnum S., Yangthara B. Comparing the Time of Passage of the First Meconium (PoFM) in Neonates With and Without Hirschsprung’s Disease (HD). Journal of the Medical Association of Thailand Vol.108 No.4 (2025) , 283-288. 288. doi:10.35755/jmedassocthai.2025.4.283-288-01540 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110681
Title
Comparing the Time of Passage of the First Meconium (PoFM) in Neonates With and Without Hirschsprung’s Disease (HD)
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Abstract
Objective: To compare the age at “passage of the first meconium” (PoFM) in neonates with and without Hirschsprung’s disease (HD) and determine the optimal cut-off age for predicting HD. Materials and Methods: A retrospective investigation was conducted on selected neonates at Siriraj Hospital, including those with HD, between January 2000 and December 2022. Results: The study included 800 neonates, including 38 with HD and 762 non-HD. At 24 hours, 3.0% of non-HD and 10.5% of HD had delayed PoFM, a statistically significant difference (p=0.035). Despite the common perception that the risk of HD increases if neonates did not pass their first meconium within the first 24 hours, 89.5% of HD patients pass their first meconium in less than a day. The median ages of PoFM were 10.5 hours for HD and 8.0 hours for non-HD, respectively, with no statistically significant difference between the groups (p=0.289). A receiver operating characteristic (ROC) curve and area under the ROC (AUC) were used to determine the optimal cut-off value of PoFM age (hour) for predicting HD. The AUC for PoFM age, in hour, was 0.551, and the optimal cut-off value could not be determined. Prenatal MgSO<inf>4</inf> or steroid therapy did not affect the age of PoFM (p=0.966 and 0.452, respectively). Conclusion: Eighty-nine-point-five percent of HD patients passed their first meconium within 24 hours. The PoFM was similar for both HD and non-HD groups.