A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development
Issued Date
2022-12-01
Resource Type
eISSN
23993642
Scopus ID
2-s2.0-85126189002
Pubmed ID
35277594
Journal Title
Communications Biology
Volume
5
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Communications Biology Vol.5 No.1 (2022)
Suggested Citation
Hikspoors J.P.J.M., Kruepunga N., Mommen G.M.C., Köhler S.E., Anderson R.H., Lamers W.H. A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development. Communications Biology Vol.5 No.1 (2022). doi:10.1038/s42003-022-03153-x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83547
Title
A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development
Other Contributor(s)
Abstract
Heart development is topographically complex and requires visualization to understand its progression. No comprehensive 3-dimensional primer of human cardiac development is currently available. We prepared detailed reconstructions of 12 hearts between 3.5 and 8 weeks post fertilization, using Amira® 3D-reconstruction and Cinema4D®-remodeling software. The models were visualized as calibrated interactive 3D-PDFs. We describe the developmental appearance and subsequent remodeling of 70 different structures incrementally, using sequential segmental analysis. Pictorial timelines of structures highlight age-dependent events, while graphs visualize growth and spiraling of the wall of the heart tube. The basic cardiac layout is established between 3.5 and 4.5 weeks. Septation at the venous pole is completed at 6 weeks. Between 5.5 and 6.5 weeks, as the outflow tract becomes incorporated in the ventricles, the spiraling course of its subaortic and subpulmonary channels is transferred to the intrapericardial arterial trunks. The remodeling of the interventricular foramen is complete at 7 weeks.