International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: Physician perspectives
Issued Date
2025-01-01
Resource Type
ISSN
16100379
eISSN
16100387
Scopus ID
2-s2.0-105007907087
Journal Title
JDDG Journal of the German Society of Dermatology
Rights Holder(s)
SCOPUS
Bibliographic Citation
JDDG Journal of the German Society of Dermatology (2025)
Suggested Citation
Pereira M.P., Stevanovic K., Kocatürk E., Meesch C., van Hofman I., Vaswani P.S., Bernstein J.A., Bruscky D., Chong-Neto H.J., Chu C.Y., Criado R.F.J., Ensina L.F., Giménez-Arnau A.M., Godse K., Gotua M., Gregoriou S., Kulthanan K., Mortz C.G., Mitrevska N.T., Özkaya E., Pudasaini P., Felix M.M.R., Pérez C.R., Parisi C.A.S., Ramón G.N., Vakirlis E., Zhao Z., Beck L.A., de Bruin-Weller M., Cork M., Katoh N., Werfel T., Worm M., Wollenberg A., Zuberbier T. International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: Physician perspectives. JDDG Journal of the German Society of Dermatology (2025). doi:10.1111/ddg.15728 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110803
Title
International survey of treatment practices for atopic dermatitis in pregnant and breastfeeding women: Physician perspectives
Author(s)
Pereira M.P.
Stevanovic K.
Kocatürk E.
Meesch C.
van Hofman I.
Vaswani P.S.
Bernstein J.A.
Bruscky D.
Chong-Neto H.J.
Chu C.Y.
Criado R.F.J.
Ensina L.F.
Giménez-Arnau A.M.
Godse K.
Gotua M.
Gregoriou S.
Kulthanan K.
Mortz C.G.
Mitrevska N.T.
Özkaya E.
Pudasaini P.
Felix M.M.R.
Pérez C.R.
Parisi C.A.S.
Ramón G.N.
Vakirlis E.
Zhao Z.
Beck L.A.
de Bruin-Weller M.
Cork M.
Katoh N.
Werfel T.
Worm M.
Wollenberg A.
Zuberbier T.
Stevanovic K.
Kocatürk E.
Meesch C.
van Hofman I.
Vaswani P.S.
Bernstein J.A.
Bruscky D.
Chong-Neto H.J.
Chu C.Y.
Criado R.F.J.
Ensina L.F.
Giménez-Arnau A.M.
Godse K.
Gotua M.
Gregoriou S.
Kulthanan K.
Mortz C.G.
Mitrevska N.T.
Özkaya E.
Pudasaini P.
Felix M.M.R.
Pérez C.R.
Parisi C.A.S.
Ramón G.N.
Vakirlis E.
Zhao Z.
Beck L.A.
de Bruin-Weller M.
Cork M.
Katoh N.
Werfel T.
Worm M.
Wollenberg A.
Zuberbier T.
Author's Affiliation
Ludwig-Maximilians-Universität München
The University of Sheffield
Charité – Universitätsmedizin Berlin
National and Kapodistrian University of Athens
University of Cincinnati
Aristotle University of Thessaloniki
University Medical Center Utrecht
Hannover Medical School
Universidade Federal do Parana
University of Rochester Medical Center
Universidade Federal de Pernambuco
Universitat Pompeu Fabra Barcelona
National Taiwan University College of Medicine
Odense Universitetshospital
İstanbul Tıp Fakültesi
Kyoto Prefectural University of Medicine
Universität Augsburg
Peking University First Hospital
Siriraj Hospital
Universitätsklinikum Schleswig-Holstein Campus Lübeck
Bahçeşehir Üniversitesi
Hospital Italiano de Buenos Aires
Centro Universitário FMABC
D Y Patil University, Navi Mumbai
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Secretaría de la Defensa Nacional
David Tvildiani Medical University
Civil Service Hospital
General Private Hospital-Remedika
Instituto de Alergia e Inmunología del Sur
GA2LEN
CPAlpha Clinical Research and Allergy Center
Alergolife ADCARE Center
ADCARE Center
The University of Sheffield
Charité – Universitätsmedizin Berlin
National and Kapodistrian University of Athens
University of Cincinnati
Aristotle University of Thessaloniki
University Medical Center Utrecht
Hannover Medical School
Universidade Federal do Parana
University of Rochester Medical Center
Universidade Federal de Pernambuco
Universitat Pompeu Fabra Barcelona
National Taiwan University College of Medicine
Odense Universitetshospital
İstanbul Tıp Fakültesi
Kyoto Prefectural University of Medicine
Universität Augsburg
Peking University First Hospital
Siriraj Hospital
Universitätsklinikum Schleswig-Holstein Campus Lübeck
Bahçeşehir Üniversitesi
Hospital Italiano de Buenos Aires
Centro Universitário FMABC
D Y Patil University, Navi Mumbai
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Secretaría de la Defensa Nacional
David Tvildiani Medical University
Civil Service Hospital
General Private Hospital-Remedika
Instituto de Alergia e Inmunología del Sur
GA2LEN
CPAlpha Clinical Research and Allergy Center
Alergolife ADCARE Center
ADCARE Center
Corresponding Author(s)
Other Contributor(s)
Abstract
Background and Objectives: Systemic treatment of pregnant/breastfeeding atopic dermatitis (AD) patients is challenging due to limited safety data. We explored treatment practices with systemic agents, including the guideline-recommended cyclosporine as the first systemic choice as well as emerging therapies, in this vulnerable population. Patients and Methods: The Global Allergy and Asthma Excellence Network (GA<sup>2</sup>LEN) ADCARE initiative collected data from physicians worldwide who treat pregnant women with AD. Physicians completed an electronic questionnaire on the use of systemic agents in pregnant/breastfeeding AD patients. Results: 103 physicians from 32 countries completed the survey, primarily dermatologists (n = 48) or allergologists (n = 43). Antihistamines were the systemic drug most often considered to be used during pregnancy/breastfeeding (n = 73/81, 90.1%), with fewer physicians considering the use of systemic agents for the first trimester compared to later stages of pregnancy. For acute flares, systemic corticosteroids (n = 34/80, 42.5%) were preferred, followed by biologics and antihistamines (each n = 15/80, 18.8%). Although the guideline-recommended cyclosporine is sometimes considered for AD during pregnancy (n = 38/81, 46.9%), it was rarely considered as the preferred drug by physicians (n = 1/80, 1.25%). Conclusions: Our study shows a misalignment between guideline recommendations and prescription patterns and highlights an unmet need for knowing and using the existing recommendations.