Contact allergy to oxidized linalool and oxidized limonene: Patch testing in consecutive patients with dermatitis
Issued Date
2022-01-01
Resource Type
ISSN
01051873
eISSN
16000536
Scopus ID
2-s2.0-85116819619
Pubmed ID
34561893
Journal Title
Contact Dermatitis
Volume
86
Issue
1
Start Page
15
End Page
24
Rights Holder(s)
SCOPUS
Bibliographic Citation
Contact Dermatitis Vol.86 No.1 (2022) , 15-24
Suggested Citation
Sukakul T. Contact allergy to oxidized linalool and oxidized limonene: Patch testing in consecutive patients with dermatitis. Contact Dermatitis Vol.86 No.1 (2022) , 15-24. 24. doi:10.1111/cod.13980 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86744
Title
Contact allergy to oxidized linalool and oxidized limonene: Patch testing in consecutive patients with dermatitis
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Background: Contact allergy to oxidized (ox.) linalool and ox. limonene has been reported to have a high prevalence, raising the question of inclusion into the baseline series. However, several important issues should be clarified and further investigated before inclusion can be warranted. Objectives: To report the trends of ox. terpenes allergy in patients with dermatitis, features of the patch test reactions, and clinical characteristics of the patients. Methods: A retrospective analysis of 5773 patients was performed. All patients were patch tested with baseline series, individual ingredients of fragrance mix I and II, ox. linalool, and ox. limonene from 2013 to 2020. Results: The prevalence rates of contact allergy to ox. linalool and ox. limonene were 7.0% and 5.1%, respectively. Significantly increasing trends of contact allergy were observed. More than 95% of contact allergy cases were identified on Day 3/4. Patients with contact allergy to ox. linalool and ox. limonene were significantly younger than those with contact allergy to other fragrances and were predominantly female. Strong reactions were associated with older age and multiple fragrance allergies. Conclusions: Contact allergy to ox. linalool and ox. limonene is becoming increasingly important, and findings show intriguing features. More studies concerning the clinical relevance before recommending these substances for screening are required.