Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multi-centre registry network
Issued Date
2022-05-07
Resource Type
ISSN
10079327
eISSN
22192840
Scopus ID
2-s2.0-85130155430
Pubmed ID
35633913
Journal Title
World Journal of Gastroenterology
Volume
28
Issue
17
Start Page
1830
End Page
1844
Rights Holder(s)
SCOPUS
Bibliographic Citation
World Journal of Gastroenterology Vol.28 No.17 (2022) , 1830-1844
Suggested Citation
Huang J.G., Wong Y.K.Y., Chew K.S., Tanpowpong P., Mercado K.S.C., Reodica A., Rajindrajith S., Chang K.C., Ni Y.H., Treepongkaruna S., Lee W.S., Aw M.M. Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multi-centre registry network. World Journal of Gastroenterology Vol.28 No.17 (2022) , 1830-1844. 1844. doi:10.3748/wjg.v28.i17.1830 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87306
Title
Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multi-centre registry network
Other Contributor(s)
Abstract
Background: There remains a dearth of Asian epidemiological literature for paediatric inflam matory bowel disease (PIBD). Aim: To describe the presenting features of PIBD from 7 Asia-Pacific pediatric gastroenterology centers via a central standardised electronic data platform. Methods: Clinical, endoscopic and radiologic data at diagnosis from the registry were extracted between 1 st January 1995 to 31 st December 2019. Disease phenotypic characteristics were classified as per the Paris classification system. Results: There was a distinct rise in new PIBD cases: Nearly half (48.6%) of the cohort was diagnosed in the most recent 5 years (2015-2019). The ratio of Crohn's disease (CD):Ulcerative colitis (UC):IBD-Unclassified was 55.9%:38.3%:5.8%. The mean age was 9.07 years with a high proportion of very early onset IBD (VEO-IBD) (29.3%) and EO-IBD (52.7%). An over-representation of the Indian/South Asian ethnic group was observed which accounted for 37.0% of the overall Singapore/Malaysia subcohort (6.8%-9.0% Indians in census). Indian/South Asian CD patients were also most likely to present with symptomatic perianal disease (P = 0.003). CD patients presented with significantly more constitutional symptoms (fever, anorexia, malaise/fatigue and muscle-wasting) than UC and higher inflammatory indices (higher C-reactive protein and lower albumin levels). Conclusion: We observed a high incidence of VEO-IBD and an over-representation of the Indian ethnicity. South Asian CD patients were more likely to have symptomatic perianal disease.