Is mold sensitization associated with severe asthma exacerbation in children?
Issued Date
2023-09-01
Resource Type
ISSN
0125877X
Scopus ID
2-s2.0-85174642371
Pubmed ID
33068372
Journal Title
Asian Pacific journal of allergy and immunology
Volume
41
Issue
3
Start Page
214
End Page
219
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific journal of allergy and immunology Vol.41 No.3 (2023) , 214-219
Suggested Citation
Leelayuwattanakul I., Visitsunthorn K., Srisuwatchari W., Pacharn P., Jirapongsananuruk O., Visitsunthorn N. Is mold sensitization associated with severe asthma exacerbation in children?. Asian Pacific journal of allergy and immunology Vol.41 No.3 (2023) , 214-219. 219. doi:10.12932/AP-210120-0743 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90843
Title
Is mold sensitization associated with severe asthma exacerbation in children?
Author's Affiliation
Other Contributor(s)
Abstract
BACKGROUND: Mold sensitization has been reported as a factor associated with severe asthma exacerbation (SAE). OBJECTIVE: To identify the factors associated with SAE in asthmatic children, particularly mold sensitization. METHODS: The asthmatic children recruited into this case-control study were classified into an SAE and an outpatient (OPD) group, based on their histories of asthma exacerbation with hospitalization in the preceding year. A skin prick test to common aeroallergens was performed. Possible SAE risk factors were analyzed. RESULTS: A total of 102 patients were enrolled. The 51 patients in the SAE group were significantly younger than the 51 in the OPD group (mean ages of 6.8 ± 3.3 vs 8.7 ±3.2 years, p = 0.005). Higher proportions of patients with partly controlled or uncontrolled asthma were found in the SAE group (41.2% vs 17.6%, p = 0.009). The incidences of a paternal history of atopy, an emergency department visit, and a history of systemic corticosteroid administration in the preceding year were significantly higher for the SAE group (35.3% vs 15.7%, p = 0.023; 100% vs 43.5%, p < 0.001; and 100% vs 31.4%, p < 0.001; respectively). The multivariate logistic regression analysis showed that risk factors for SAE were Alternaria sensitization (adjusted odds ratio [AOR] 3.00; 95% CI 1.09-8.3; p = 0.033), patients who were younger than 6 years (AOR 3.28; 95% CI 1.17-9.18; p = 0.024), and a paternal history of atopy (AOR 2.94; 95% CI 1.05-8.25; p = 0.040). CONCLUSIONS: Alternaria sensitization, an age younger than 6 years, and a paternal history of atopy were associated with SAE in asthmatic children.