The history of cytokines and growth factors development
Issued Date
2025-03-01
Resource Type
ISSN
15216926
eISSN
15321924
Scopus ID
2-s2.0-105000730451
Journal Title
Best Practice and Research: Clinical Haematology
Volume
38
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Best Practice and Research: Clinical Haematology Vol.38 No.1 (2025)
Suggested Citation
Kungwankiattichai S., Maziarz R.T. The history of cytokines and growth factors development. Best Practice and Research: Clinical Haematology Vol.38 No.1 (2025). doi:10.1016/j.beha.2025.101612 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/108571
Title
The history of cytokines and growth factors development
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Author's Affiliation
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Abstract
The discovery and development of cytokines and growth factors represent transformative events in modern medicine, spanning from early observations of immune mediators to current therapeutic applications. This review chronicles the historical progression from the initial identification of permeability factors in 1926 to contemporary engineered cytokine therapeutics. Key milestones include the discovery of interferon (1957), the characterization of colony-stimulating factors, and the development of recombinant proteins in the 1980s. The field has evolved from basic understanding of immune communication to sophisticated therapeutic interventions, including targeted inhibitors and engineered cell therapies. While significant advances have been made in treating various diseases through cytokine modulation, challenges remain in managing pleiotropic effects and optimizing delivery systems. Recent innovations in bioengineering and cell therapy suggest promising directions for future therapeutic applications.