Smart colorimetric label based on chitosan-grafted cresol red for early detection of catheter blockage and infection through urinary pH monitoring
Issued Date
2025-12-01
Resource Type
ISSN
01418130
eISSN
18790003
Scopus ID
2-s2.0-105020023703
Pubmed ID
41138872
Journal Title
International Journal of Biological Macromolecules
Volume
332
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Biological Macromolecules Vol.332 (2025)
Suggested Citation
Keawdoungdee A., Chalitangkoon J., Sirithanakorn C., Kamolvit W., Detsri E., Monvisade P. Smart colorimetric label based on chitosan-grafted cresol red for early detection of catheter blockage and infection through urinary pH monitoring. International Journal of Biological Macromolecules Vol.332 (2025). doi:10.1016/j.ijbiomac.2025.148512 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112903
Title
Smart colorimetric label based on chitosan-grafted cresol red for early detection of catheter blockage and infection through urinary pH monitoring
Corresponding Author(s)
Other Contributor(s)
Abstract
This study presents a smart, non-invasive colorimetric sensor designed for the early detection of catheter-associated urinary tract infections (CAUTIs) and impending catheter blockage. The sensor was developed by covalently grafting cresol red onto chitosan (CS-g-CR) via a Mannich reaction, producing a biocompatible, pH-responsive material exhibiting strong dye retention and stable, visible color transitions across the urinary pH range. The material was formulated into a water-based screen-printable ink and applied to cotton fabric, yielding flexible labels capable of detecting alkaline shifts associated with Proteus mirabilis infection. In an in vitro bladder model, the printed labels provided up to 20 h of advance warning prior to complete catheter blockage. Color changes were quantified using smartphone-based RGB analysis, enabling objective and real-time monitoring. This low-cost sensing platform holds promise for point-of-care applications aimed at improving early diagnosis and reducing complications in long-term catheterized patients.