Sacha inchi meal protein hydrolysate mitigates lipid accumulation and oxidative stress in HepG2 and 3 T3-L1 cells and synergistically enhances captopril's antihypertensive effects in L-NAME-induced hypertensive rats
Issued Date
2025-04-01
Resource Type
ISSN
17564646
Scopus ID
2-s2.0-105000797192
Journal Title
Journal of Functional Foods
Volume
127
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Functional Foods Vol.127 (2025)
Suggested Citation
Sa-nguanpong P., Wetprasit P., Inchan A., Chaichana C., Kaewkong W., Charoenphon N., Adthapanyawanich K., Tantanarat K., Tochampa W., Ruttarattanamongkol K., Bualeong T. Sacha inchi meal protein hydrolysate mitigates lipid accumulation and oxidative stress in HepG2 and 3 T3-L1 cells and synergistically enhances captopril's antihypertensive effects in L-NAME-induced hypertensive rats. Journal of Functional Foods Vol.127 (2025). doi:10.1016/j.jff.2025.106772 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/108621
Title
Sacha inchi meal protein hydrolysate mitigates lipid accumulation and oxidative stress in HepG2 and 3 T3-L1 cells and synergistically enhances captopril's antihypertensive effects in L-NAME-induced hypertensive rats
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Abstract
This study evaluates the antihypertensive effects of Sacha Inchi meal protein hydrolysate (SIPH) in L-NAME-induced hypertensive rats. Male Sprague Dawley rats treated with L-NAME (40 mg/kg) received SIPH (100, 300, or 500 mg/kg), captopril (5 mg/kg), or a combination of captopril (2.5 mg/kg) and SIPH (500 mg/kg) for 5 weeks. Blood pressure was monitored weekly and verified via carotid artery cannulation. SIPH at 500 mg/kg, incombination with captopril, significantly reduced blood pressure, upregulated eNOS expression, alleviated renal and liver injury, enhanced sperm viability, and downregulated VCAM-1 expression. In HepG2 and 3 T3-L1 cells, SIPH mitigated oxidative stress, hepatic steatosis, and lipid accumulation. Together, these in vitro and in vivo findings suggest that SIPH could serve as a promising nutraceutical candidate for antihypertensive functional foods.