The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Zoonotic Avian Influenza and Mycobacterium tuberculosis
Issued Date
2023-09-01
Resource Type
ISSN
15356760
eISSN
24701246
Scopus ID
2-s2.0-85173228053
Journal Title
Applied Biosafety
Volume
28
Issue
3
Start Page
135
End Page
151
Rights Holder(s)
SCOPUS
Bibliographic Citation
Applied Biosafety Vol.28 No.3 (2023) , 135-151
Suggested Citation
Blacksell S.D., Dhawan S., Kusumoto M., Le K.K., Summermatter K., O’Keefe J., Kozlovac J., Almuhairi S.S., Sendow I., Scheel C.M., Ahumibe A., Masuku Z.M., Bennett A.M., Kojima K., Harper D.R., Hamilton K. The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Zoonotic Avian Influenza and Mycobacterium tuberculosis. Applied Biosafety Vol.28 No.3 (2023) , 135-151. 151. doi:10.1089/apb.2022.0038 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90506
Title
The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Zoonotic Avian Influenza and Mycobacterium tuberculosis
Author's Affiliation
World Organisation for Animal Health (WOAH)
Badan Riset dan Inovasi Nasional
UK Health Security Agency
Mahidol Oxford Tropical Medicine Research Unit
Nigeria Centre for Disease Control
National Institute for Communicable Diseases
Organisation Mondiale de la Santé
Centers for Disease Control and Prevention
Chatham House
University of Bern
Nuffield Department of Medicine
USDA ARS Beltsville Agricultural Research Center
Abu Dhabi Agriculture and Food Safety Authority
National Emergency Crisis and Disasters Management Authority
Ministry for Primary Industries
Badan Riset dan Inovasi Nasional
UK Health Security Agency
Mahidol Oxford Tropical Medicine Research Unit
Nigeria Centre for Disease Control
National Institute for Communicable Diseases
Organisation Mondiale de la Santé
Centers for Disease Control and Prevention
Chatham House
University of Bern
Nuffield Department of Medicine
USDA ARS Beltsville Agricultural Research Center
Abu Dhabi Agriculture and Food Safety Authority
National Emergency Crisis and Disasters Management Authority
Ministry for Primary Industries
Other Contributor(s)
Abstract
Introduction: The Biosafety Research Road Map reviewed the scientific literature on a viral respiratory pathogen, avian influenza virus, and a bacterial respiratory pathogen, Mycobacterium tuberculosis. This project aims at identifying gaps in the data required to conduct evidence-based biorisk assessments, as described in Blacksell et al. One significant gap is the need for definitive data on M. tuberculosis sample aerosolization to guide the selection of engineering controls for diagnostic procedures. Methods: The literature search focused on five areas: routes of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination methods. Results: The available data regarding biosafety knowledge gaps and existing evidence have been collated and presented in Tables 1 and 2. The guidance sources on the appropriate use of biosafety cabinets for specific procedures with M. tuberculosis require clarification. Detecting vulnerabilities in the biorisk assessment for respiratory pathogens is essential to improve and develop laboratory biosafety in local and national systems.