Efficacy of isobutylamido thiazolyl resorcinol for prevention of laser-induced post-inflammatory hyperpigmentation: A randomized, controlled trial
Issued Date
2024-01-01
Resource Type
ISSN
14732130
eISSN
14732165
Scopus ID
2-s2.0-85188452314
Pubmed ID
38497328
Journal Title
Journal of Cosmetic Dermatology
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SCOPUS
Bibliographic Citation
Journal of Cosmetic Dermatology (2024)
Suggested Citation
Vachiramon V., Sakpuwadol N., Yongpisarn T., Anuntrangsee T., Palakornkitti P. Efficacy of isobutylamido thiazolyl resorcinol for prevention of laser-induced post-inflammatory hyperpigmentation: A randomized, controlled trial. Journal of Cosmetic Dermatology (2024). doi:10.1111/jocd.16287 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97786
Title
Efficacy of isobutylamido thiazolyl resorcinol for prevention of laser-induced post-inflammatory hyperpigmentation: A randomized, controlled trial
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Abstract
Background: Q-switched (QS) Nd: YAG laser is one of the treatment options for solar lentigines (SLs). However, the incidence of post-inflammatory hyperpigmentation (PIH) is a common complication, especially in dark-complexioned skin. Isobutylamido thiazolyl resorcinol (ITR) has been reported as a preventive modality for ultraviolet B (UVB)-induced hyperpigmentation. Aims: This study aims to evaluate the efficacy and safety of ITR for the prevention of laser-induced PIH. Patients/Methods: A randomized, evaluator-blinded study including 24 subjects with SLs was conducted. Three SLs of each patient were randomized into three groups, which were to apply ITR twice daily, once daily, and no application for 2 weeks. Thereafter, 532-nm QS Nd: YAG laser was performed. Incidence of laser-induced PIH, relative melanin index (RMI), mean luminance score (L*), hyperpigmentation score, and adverse events were recorded for 2 months post-laser. Results: The incidence of PIH at the 4th week after laser treatment was significantly lower in the ITR twice-daily group compared to the no-application group (20.83% vs. 50%, p = 0.028). There was no statistically significant difference in RMI, mean L*, and hyperpigmentation score between treatments at all visits. No serious adverse events were reported regarding ITR application and laser treatment. Conclusion: Two-week application of ITR prior to QS: Nd YAG laser treatment may potentially reduce the incidence of PIH. A longer duration of application, including after the laser procedure, may be more beneficial for the prevention of laser-induced PIH.