Incidence of Myocardial Injury and Cardiac Dysfunction after Adult Traumatic Brain Injury: A Systematic Review and Meta-analysis
Issued Date
2024-10-01
Resource Type
ISSN
08984921
eISSN
15371921
Scopus ID
2-s2.0-85192696304
Pubmed ID
39240312
Journal Title
Journal of Neurosurgical Anesthesiology
Volume
36
Issue
4
Start Page
283
End Page
293
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Neurosurgical Anesthesiology Vol.36 No.4 (2024) , 283-293
Suggested Citation
Chaikittisilpa N., Kiatchai T., Liu S.Y., Kelly-Hedrick M., Vavilala M.S., Lele A.V., Komisarow J., Ohnuma T., Colton K., Krishnamoorthy V. Incidence of Myocardial Injury and Cardiac Dysfunction after Adult Traumatic Brain Injury: A Systematic Review and Meta-analysis. Journal of Neurosurgical Anesthesiology Vol.36 No.4 (2024) , 283-293. 293. doi:10.1097/ANA.0000000000000945 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101319
Title
Incidence of Myocardial Injury and Cardiac Dysfunction after Adult Traumatic Brain Injury: A Systematic Review and Meta-analysis
Corresponding Author(s)
Other Contributor(s)
Abstract
Myocardial injury and cardiac dysfunction after traumatic brain injury (TBI) have been reported in observational studies, but there is no robust estimate of their incidences. We conducted a systematic review and meta-analysis to estimate the pooled incidence of myocardial injury and cardiac dysfunction among adult patients with TBI. A literature search was conducted using MEDLINE and EMBASE databases from inception to November 2022. Observational studies were included if they reported at least one abnormal electrocardiographic finding, elevated cardiac troponin level, or echocardiographic evaluation of systolic function or left ventricular wall motion in adult patients with TBI. Myocardial injury was defined as elevated cardiac troponin level according to the original studies and cardiac dysfunction was defined as the presence of left ventricular ejection fraction <50% or regional wall motion abnormalities assessed by echocardiography. The meta-analysis of the pooled incidence of myocardial injury and cardiac dysfunction was performed using random-effect models. The pooled estimated incidence of myocardial injury after TBI (17 studies, 3,773 participants) was 33% (95% CI: 27%-39%, I 2:s 93%), and the pooled estimated incidence of cardiac dysfunction after TBI (9 studies, 557 participants) was 16.% (95% CI: 9%-25.%, I 2: 84%). Although there was significant heterogeneity between studies and potential overestimation of the incidence of myocardial injury and cardiac dysfunction, our findings suggest that myocardial injury occurs in approximately one-third of adults after TBI, and cardiac dysfunction occurs in approximately one-sixth of patients with TBI.