Prevalence, anti-malarial chemoprophylaxis and causes of deaths for severe imported malaria: A systematic review and meta-analysis
Issued Date
2022-09-01
Resource Type
ISSN
14778939
eISSN
18730442
Scopus ID
2-s2.0-85136090594
Pubmed ID
35985533
Journal Title
Travel Medicine and Infectious Disease
Volume
49
Rights Holder(s)
SCOPUS
Bibliographic Citation
Travel Medicine and Infectious Disease Vol.49 (2022)
Suggested Citation
Mahittikorn A., Mala W., Wilairatana P., Siri S., Masangkay F.R., Kotepui K.U., Kotepui M. Prevalence, anti-malarial chemoprophylaxis and causes of deaths for severe imported malaria: A systematic review and meta-analysis. Travel Medicine and Infectious Disease Vol.49 (2022). doi:10.1016/j.tmaid.2022.102408 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85585
Title
Prevalence, anti-malarial chemoprophylaxis and causes of deaths for severe imported malaria: A systematic review and meta-analysis
Other Contributor(s)
Abstract
Background: There are limited data regarding prevalence, anti-malarial chemoprophylaxis, and causes of death for severe imported malaria. Thus, we conducted a systematic review and meta-analysis to characterise these variables. Methods: We searched studies reporting deaths attributable to severe imported malaria. The following pooled prevalence rates were determined: 1) the pooled prevalence of severe malaria among patients with imported malaria, 2) the pooled prevalence of deaths among patients with severe imported malaria, 3) the pooled prevalence of anti-malarial chemoprophylaxis among patients with severe imported malaria, and 4) the causes of death among patients with severe imported malaria. Results: The search identified 52 studies that were mainly conducted in Europe (25, 48.1%), North America (16, 30.8%) and Asia (7, 13.5%). The pooled prevalence of severe imported malaria was 12.5% (95% confidence interval [CI] = 10.3%–14.6%, I2 = 99.32%, 12393 severe cases/118325 imported cases). The pooled prevalence of deaths attributable to severe imported malaria was 5.1% (95% CI = 4.0%–6.2%, I2 = 91.72%, 721 deaths/16310 severe cases). The pooled prevalence of adequate anti-malarial chemoprophylaxis among patients with severe imported malaria was 9.7% (95% CI = 6.5%–13.0%, I2 = 89.9%, 203/2049 cases). The most common cause of death was multi-organ failure (12.3%). Conclusion: The results highlighted the need for education and preventative measures for travellers, immigrants, or workers who plan to visit malaria-endemic areas to minimize the risk of severe disease or death.