Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx)
Issued Date
2022-01-01
Resource Type
ISSN
00406376
eISSN
14683296
Scopus ID
2-s2.0-85107683532
Pubmed ID
34088787
Journal Title
Thorax
Volume
77
Issue
1
Start Page
79
End Page
81
Rights Holder(s)
SCOPUS
Bibliographic Citation
Thorax Vol.77 No.1 (2022) , 79-81
Suggested Citation
Van Oort P.M.P. Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx). Thorax Vol.77 No.1 (2022) , 79-81. 81. doi:10.1136/thoraxjnl-2021-217362 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87446
Title
Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx)
Author(s)
Author's Affiliation
Faculty of Biology, Medicine and Health
University of Nova Gorica
University of Strathclyde
University of Liverpool
Philips Research
Mahidol University
Trinity College Dublin
Hospital de Sabadell
The University of Manchester
Wythenshawe Hospital
Amsterdam UMC - University of Amsterdam
Orikami
Eurofins Materials Science Netherlands BV
Centro Hospitalar de Lisboa Central
University of Nova Gorica
University of Strathclyde
University of Liverpool
Philips Research
Mahidol University
Trinity College Dublin
Hospital de Sabadell
The University of Manchester
Wythenshawe Hospital
Amsterdam UMC - University of Amsterdam
Orikami
Eurofins Materials Science Netherlands BV
Centro Hospitalar de Lisboa Central
Other Contributor(s)
Abstract
Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.