Modeling diet-gut microbiome interactions and prebiotic responses in Thai adults
1
Issued Date
2026-01-28
Resource Type
eISSN
20555008
Scopus ID
2-s2.0-105032713377
Pubmed ID
41605932
Journal Title
Npj Biofilms and Microbiomes
Volume
12
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Npj Biofilms and Microbiomes Vol.12 No.1 (2026)
Suggested Citation
Raethong N., Patumcharoenpol P., Vongsangnak W. Modeling diet-gut microbiome interactions and prebiotic responses in Thai adults. Npj Biofilms and Microbiomes Vol.12 No.1 (2026). doi:10.1038/s41522-026-00921-z Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115775
Title
Modeling diet-gut microbiome interactions and prebiotic responses in Thai adults
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Author's Affiliation
Corresponding Author(s)
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Abstract
The impact of diet on gut microbial metabolism is essential for advancing microbiome-based health interventions. This study introduces a novel systems biology pipeline that integrates genome-scale metabolic models (GSMMs) with Thai dietary intake data to simulate gut microbiome metabolism and assess prebiotic responses. Utilizing metagenomic data from healthy Thai adults and an average Thai diet derived from national surveys, community-scale metabolic models (CSMMs) were developed and simulated under both typical dietary and prebiotic-supplemented condition. Flux variability analysis was employed to assess metabolic capacities, short-chain fatty acids (SCFAs) production in relation to microbial taxonomy. The results promisingly revealed inter-individual variability in SCFA profiles, with Bacteroides and Phocaeicola notably linked to isobutyrate production and Bifidobacterium emerged as a key responder to prebiotic supplementation. This integrative framework offers biological insights into diet-gut microbiome interactions and provides a foundation for the development of precision nutrition strategies tailored to the Thai population.