Psychosocial adaptation and influencing factors among patients with chemotherapy-induced peripheral neuropathy
Issued Date
2022-05-26
Resource Type
eISSN
23078960
Scopus ID
2-s2.0-85131084231
Journal Title
World Journal of Clinical Cases
Volume
10
Issue
15
Start Page
4843
End Page
4855
Rights Holder(s)
SCOPUS
Bibliographic Citation
World Journal of Clinical Cases Vol.10 No.15 (2022) , 4843-4855
Suggested Citation
Zhou X., Wang D.Y., Ding C.Y., Liu H., Sun Z.Q. Psychosocial adaptation and influencing factors among patients with chemotherapy-induced peripheral neuropathy. World Journal of Clinical Cases Vol.10 No.15 (2022) , 4843-4855. 4855. doi:10.12998/wjcc.v10.i15.4843 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85866
Title
Psychosocial adaptation and influencing factors among patients with chemotherapy-induced peripheral neuropathy
Other Contributor(s)
Abstract
BACKGROUND Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and longlasting side effect caused by various anticancer agents that damage sensory, motor and autonomic nerves. It can cause maladaptive behaviors, including disease severity, anxiety, depression, sleep disorders, falls, and social impairment. These disorders have physical, psychological and social effects on patients and can seriously influence their quality of life. AIM To investigate the current situation of psychosocial adaptation to the disease and its influencing factor in patients with CIPN. METHODS A convenience sampling method was used to select 233 patients with CIPN in our hospital from February to August 2021. In addition, a cross-sectional survey was conducted using a sociodemographic questionnaire, the Self-Report Psychosocial Adjustment to Illness Scale, and the European Organisation for the Research and Treatment of Cancer Quality of Life CIPN20 (QLQ-CIPN20). Factors influencing psychosocial adaptation in patients with CIPN were analyzed by t-test or one-way analysis of variance, correlation analysis, multiple stepwise regression analysis, and structural equation models. RESULTS The psychosocial adaptation score of patients with CIPN was 52.51 ± 13.18. Multivariate analysis showed that autonomic nerves, tumor stage, motor nerves, education level, availability of caregivers, semi-retirement status, CIPN grade were independent risk factors for patients with CIPN (P < 0.05). Structural equation models showed that QLQ-CIPN20 mediated the relationship between CIPN grade, tumor stage, and psychosocial adaptation. CONCLUSION Patients with CIPN have poor psychosocial adaptation and are affected by a variety of physiological, psychological, and social factors. Patients’ adaptive responses should be assessed, and targeted interventions implemented.