Prevalence of concomitant angioedema in chronic spontaneous urticaria: A systematic review and meta-analysis
2
Issued Date
2023-03-01
Resource Type
ISSN
0125877X
Scopus ID
2-s2.0-85151963399
Pubmed ID
37029783
Journal Title
Asian Pacific journal of allergy and immunology
Volume
41
Issue
1
Start Page
12
End Page
19
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific journal of allergy and immunology Vol.41 No.1 (2023) , 12-19
Suggested Citation
Weerasubpong P. Prevalence of concomitant angioedema in chronic spontaneous urticaria: A systematic review and meta-analysis. Asian Pacific journal of allergy and immunology Vol.41 No.1 (2023) , 12-19. 19. doi:10.12932/AP-151222-1515 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/81932
Title
Prevalence of concomitant angioedema in chronic spontaneous urticaria: A systematic review and meta-analysis
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
BACKGROUND: Angioedema (AE) is a condition associated with considerable morbidity and mortality that can significantly affect quality of life. AE often occurs in patients with CSU although the true prevalence remains unknown. Therefore, we conducted this systematic review and meta-analysis to summarize the available data. OBJECTIVE: This study is conducted with the aim of retrieving data from all published studies and create the pooled prevalence of AE in CSU patients. METHODS: Narrative reviews of AE and CSU, a systematic review, and a meta-analysis were conducted. The Ovid Medline and Embase databases were systematically searched per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Studies were eligible if they were in English and measured the prevalence of AE in CSU in adults or children. Two reviewers independently extracted data and appraised each study's quality. Estimated prevalence and 95% confidence interval (CI) values were pooled using random-effects meta-analysis. RESULTS: Seventeen studies from 16 countries were included. The pooled prevalence of AE in patients with CSU was 36.5% (95%CI, 30.9-42.5%; I2 = 96%). The pooled estimated prevalence of AE in patients with CSU was 44.0% (95%CI, 34.1-54.5%) in Europe, 44.5% (95%CI, 28.5-61.8%), America, and 29.4% (95%CI, 24.7-34.7%) in Asia. CONCLUSIONS: Our systematic review and meta?analysis showed that AE affects over one-third of CSU patients, although the prevalence from individual study varied considerably, ranging from 5 to 67 percent. Subgroup-analysis found that AE is more prevalent in Europe and America than in Asia.