Comparative proteomic analysis of male and female androgenetic alopecia: elucidating gender-specific molecular patterns
Issued Date
2024-10-26
Resource Type
eISSN
1432069X
Scopus ID
2-s2.0-85207857379
Pubmed ID
39460779
Journal Title
Archives of dermatological research
Volume
316
Issue
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Archives of dermatological research Vol.316 No.10 (2024) , 721
Suggested Citation
Charoensuksira S., Meephansan J., Vanichvongvan R., Somparn P., Tangtanatakul P., Wongpiyabovorn J., Suchonwanit P. Comparative proteomic analysis of male and female androgenetic alopecia: elucidating gender-specific molecular patterns. Archives of dermatological research Vol.316 No.10 (2024) , 721. doi:10.1007/s00403-024-03453-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101937
Title
Comparative proteomic analysis of male and female androgenetic alopecia: elucidating gender-specific molecular patterns
Corresponding Author(s)
Other Contributor(s)
Abstract
This study presents a comprehensive comparative proteomic analysis aimed at elucidating the molecular mechanisms underlying male androgenetic alopecia (AGA) and female AGA. Scalp samples from both male AGA and female AGA patients, along with their respective normal controls, were subjected to proteomic analysis, followed by bioinformatics investigations. Our findings revealed distinct proteomic profiles between male AGA and female AGA, with a total of 68 differentially expressed proteins identified in male AGA and 84 in female AGA. Among these, specific proteins were altered in male AGA and female AGA, highlighting the sex-specific molecular pathways involved in the pathogenesis of pattern hair loss. Protein-protein interaction network analyses further delineated the most impacted biological processes, including cytoskeleton organization, stress response, and metabolic pathways, with particular emphasis on the differing altered stress responses and metabolic states associated with hair loss between sexes. Our study not only uncovered the complex molecular landscape of male AGA and female AGA but also identified potential biomarkers and therapeutic targets, offering new insights into the sex-specific pathogenesis of pattern hair loss.