Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis
Issued Date
2025-11-14
Resource Type
eISSN
14752875
Scopus ID
2-s2.0-105021980758
Pubmed ID
41239453
Journal Title
Malaria Journal
Volume
24
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Malaria Journal Vol.24 No.1 (2025) , 400
Suggested Citation
Edler P., Rajasekhar M., Price D.J., Adam I., Awab G.R., Barber B.E., Brasil L.W., Chamma-Siqueira N.N., Chu C.S., Cui L., Daher A., Gomes M.d.S.M., Gonzalez-Ceron L., Grigg M.J., Karunajeewa H., Lacerda M.V.G., Ladeia-Andrade S., Leslie T., Ley B., Lidia K., Llanos-Cuentas A., Longley R.J., Manning L., Mekonnen D.A., Monteiro W.M., Moore B.R., Nosten F., Pasaribu A.P., Pereira D.B., Poespoprodjo J.R., Pukrittayakamee S., Rijal K.R., Saravu K., Siqueira A.M., Sutanto I., Taylor W.R.J., Thanh P.V., Thriemer K., Vieira J.L.F., White N.J., Yeshiwondim A.K., Zuluaga-Idarraga L.M., Guerin P.J., Simpson J.A., Price R.N., Commons R.J. Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis. Malaria Journal Vol.24 No.1 (2025) , 400. doi:10.1186/s12936-025-05642-w Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113201
Title
Automated reporting of primaquine dose efficacy, tolerability and safety for Plasmodium vivax malaria using a systematic review and individual patient data meta-analysis
Author(s)
Edler P.
Rajasekhar M.
Price D.J.
Adam I.
Awab G.R.
Barber B.E.
Brasil L.W.
Chamma-Siqueira N.N.
Chu C.S.
Cui L.
Daher A.
Gomes M.d.S.M.
Gonzalez-Ceron L.
Grigg M.J.
Karunajeewa H.
Lacerda M.V.G.
Ladeia-Andrade S.
Leslie T.
Ley B.
Lidia K.
Llanos-Cuentas A.
Longley R.J.
Manning L.
Mekonnen D.A.
Monteiro W.M.
Moore B.R.
Nosten F.
Pasaribu A.P.
Pereira D.B.
Poespoprodjo J.R.
Pukrittayakamee S.
Rijal K.R.
Saravu K.
Siqueira A.M.
Sutanto I.
Taylor W.R.J.
Thanh P.V.
Thriemer K.
Vieira J.L.F.
White N.J.
Yeshiwondim A.K.
Zuluaga-Idarraga L.M.
Guerin P.J.
Simpson J.A.
Price R.N.
Commons R.J.
Rajasekhar M.
Price D.J.
Adam I.
Awab G.R.
Barber B.E.
Brasil L.W.
Chamma-Siqueira N.N.
Chu C.S.
Cui L.
Daher A.
Gomes M.d.S.M.
Gonzalez-Ceron L.
Grigg M.J.
Karunajeewa H.
Lacerda M.V.G.
Ladeia-Andrade S.
Leslie T.
Ley B.
Lidia K.
Llanos-Cuentas A.
Longley R.J.
Manning L.
Mekonnen D.A.
Monteiro W.M.
Moore B.R.
Nosten F.
Pasaribu A.P.
Pereira D.B.
Poespoprodjo J.R.
Pukrittayakamee S.
Rijal K.R.
Saravu K.
Siqueira A.M.
Sutanto I.
Taylor W.R.J.
Thanh P.V.
Thriemer K.
Vieira J.L.F.
White N.J.
Yeshiwondim A.K.
Zuluaga-Idarraga L.M.
Guerin P.J.
Simpson J.A.
Price R.N.
Commons R.J.
Author's Affiliation
University of Melbourne
Curtin University
London School of Hygiene & Tropical Medicine
The University of Texas Medical Branch at Galveston
Fundacao Oswaldo Cruz
Universitas Indonesia
Organisation Mondiale de la Santé
Universitas Gadjah Mada
Morsani College of Medicine
Universidad de Antioquia
Universidade Federal do Pará
Nuffield Department of Medicine
Qassim University
QIMR Berghofer Medical Research Institute
Universitas Sumatera Utara
Walter and Eliza Hall Institute of Medical Research
Kasturba Medical College, Manipal
Tribhuvan University
The Kids Research Institute Australia
Instituto Nacional de Salud Publica
Faculty of Tropical Medicine, Mahidol University
UWA Medical School
Menzies School of Health Research
Haramaya University
Melbourne Medical School
Fiona Stanley Hospital
Instituto Nacional de Infectologia Evandro Chagas (INI)
Mahidol Oxford Tropical Medicine Research Unit
Universidade do Estado do Amazonas
Instituto de Higiene e Medicina Tropical
Centre for Epidemiology and Biostatistics
Instituto Evandro Chagas
Universidade Federal do Amapa
Fundacao Universidade Federal de Rondonia
Curtin Medical School
Armauer Hansen Research Institute
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt
Department of Infectious Diseases
Fiocruz Amazônia
Universitas Nusa Cendana
Fundacao de Medicina Tropical do Amazonas
WorldWide Antimalarial Resistance Network
Health Works, Amsterdam
Infectious Diseases Data Observatory
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Natl. Inst. Malariology
Centro de Pesquisa em Medicina Tropical de Rondônia
Mimika District Hospital
Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit
Afghan International Islamic University
Asia-Pacific Regional Centre
Papuan Health and Community Development Foundation
General and Subspecialty Medicine
Curtin University
London School of Hygiene & Tropical Medicine
The University of Texas Medical Branch at Galveston
Fundacao Oswaldo Cruz
Universitas Indonesia
Organisation Mondiale de la Santé
Universitas Gadjah Mada
Morsani College of Medicine
Universidad de Antioquia
Universidade Federal do Pará
Nuffield Department of Medicine
Qassim University
QIMR Berghofer Medical Research Institute
Universitas Sumatera Utara
Walter and Eliza Hall Institute of Medical Research
Kasturba Medical College, Manipal
Tribhuvan University
The Kids Research Institute Australia
Instituto Nacional de Salud Publica
Faculty of Tropical Medicine, Mahidol University
UWA Medical School
Menzies School of Health Research
Haramaya University
Melbourne Medical School
Fiona Stanley Hospital
Instituto Nacional de Infectologia Evandro Chagas (INI)
Mahidol Oxford Tropical Medicine Research Unit
Universidade do Estado do Amazonas
Instituto de Higiene e Medicina Tropical
Centre for Epidemiology and Biostatistics
Instituto Evandro Chagas
Universidade Federal do Amapa
Fundacao Universidade Federal de Rondonia
Curtin Medical School
Armauer Hansen Research Institute
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt
Department of Infectious Diseases
Fiocruz Amazônia
Universitas Nusa Cendana
Fundacao de Medicina Tropical do Amazonas
WorldWide Antimalarial Resistance Network
Health Works, Amsterdam
Infectious Diseases Data Observatory
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Natl. Inst. Malariology
Centro de Pesquisa em Medicina Tropical de Rondônia
Mimika District Hospital
Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit
Afghan International Islamic University
Asia-Pacific Regional Centre
Papuan Health and Community Development Foundation
General and Subspecialty Medicine
Corresponding Author(s)
Other Contributor(s)
Abstract
BACKGROUND: The antirelapse efficacy of primaquine is related to the total dose administered, whereas the risks of haemolysis and gastrointestinal intolerance are associated with the daily dose administered. National Malaria Control Programmes require local information on efficacy, tolerability and safety to optimize antimalarial treatment policies for Plasmodium vivax malaria control and elimination efforts. METHODS: A living systematic review identified efficacy studies of uncomplicated P. vivax malaria including patients treated with daily primaquine regimens, published since January 1, 2000. Available data were pooled and an R Shiny app was developed to integrate statistical analyses performed using R and Stata that assessed the impact of primaquine mg/kg dose on efficacy, hematological safety and gastrointestinal tolerability. RESULTS: As of January 16, 2025, a total of 9,270 individual patient data records from 41 studies have been collated into the standardized repository. Open-access automated reports were generated for user-selected countries or regions to investigate location specific effects of primaquine dose on efficacy, safety and tolerability. The reports include visual and tabular displays of the outcomes. CONCLUSIONS: These automated reports leverage a large database to provide accessible data for national and regional policy makers and researchers to assess the clinical consequences of different primaquine regimens in different endemic settings. The reports will inform local and regional policy decisions and research priorities in vivax-endemic areas.