The infection of Cysticercus fasciolaris in natural rats (Rattus species) residing in human residence areas, Nakhon Si Thammarat, Thailand
Issued Date
2024-04-01
Resource Type
ISSN
01479571
eISSN
18781667
Scopus ID
2-s2.0-85186649461
Journal Title
Comparative Immunology, Microbiology and Infectious Diseases
Volume
107
Rights Holder(s)
SCOPUS
Bibliographic Citation
Comparative Immunology, Microbiology and Infectious Diseases Vol.107 (2024)
Suggested Citation
Thaikoed S., Mitsuwan W., Chaisiri K., Tanthanathipchai N., de Lourdes Pereira M., Paul A.K., Nissapatorn V., Saengsawang P. The infection of Cysticercus fasciolaris in natural rats (Rattus species) residing in human residence areas, Nakhon Si Thammarat, Thailand. Comparative Immunology, Microbiology and Infectious Diseases Vol.107 (2024). doi:10.1016/j.cimid.2024.102152 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97520
Title
The infection of Cysticercus fasciolaris in natural rats (Rattus species) residing in human residence areas, Nakhon Si Thammarat, Thailand
Corresponding Author(s)
Other Contributor(s)
Abstract
Cysticercus fasciolaris (C. fasciolaris) is the larval stage of a cestode parasite named Taenia taeniaeformis (T. taeniaeformis). C. fasiolaris is found in small rodents, especially rats. Rattus species are listed as intermediate hosts of this parasite, and cats are the main definitive host of C. fasiolaris. The objective of this study was to study the pathological, microscopic, and molecular aspects of C. fasciolaris in rodents residing in human residence areas. One hundred and two rodents were trapped in human settlements and dissected for larva-containing cyst examinations in the body cavity. The larvae of C. fasciolaris were investigated using histopathological examination, microscopic observations under a stereomicroscope and scanning electron microscope, and molecular detection using polymerase chain reaction. The prevalence of hepatic cysts containing larvae was 8.91% (95% CI = 4.16–16.24). In addition, the older larvae also had longer micropapillae. Histopathological investigation revealed normal hepatic tissue containing larvae and a scanty fluid cyst. The cyst capsule contains mostly mononuclear cells and spindle cells in all infected rats. The molecular detection using two primer sets revealed the amplicons were similar to the clade of C. fasciolaris. In the future, more investigation is necessary to fully understand the parasite's molecular pathogenesis and virulent molecules, which are less obvious.